caryophyllene oxide

has butyrylcholinesterase inhibitory activity; structure in first source

Also Known As:

4,12,12-trimethyl-9-methylene-5-oxatricyclo(8.2.0.04,6)dodecane; beta-caryophyllene epoxide; beta-caryophyllene oxide

Networked: 29 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        caryophyllene oxide: 29
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - caryophyllene oxide: 29

Experts

1.	Ambrož, Martin: 4 articles (03/2019 - 08/2015)
2.	Skálová, Lenka: 4 articles (03/2019 - 08/2015)
3.	Di Giacomo, Silvia: 3 articles (11/2021 - 01/2019)
4.	Di Sotto, Antonella: 3 articles (11/2021 - 01/2019)
5.	Mazzanti, Gabriela: 3 articles (01/2020 - 01/2017)
6.	Králová, Věra: 3 articles (03/2019 - 08/2015)
7.	Skarka, Adam: 3 articles (11/2017 - 08/2015)
8.	Ahn, Kwang Seok: 3 articles (10/2014 - 12/2011)
9.	Cho, Somi K: 3 articles (10/2014 - 12/2011)
10.	Sethi, Gautam: 3 articles (10/2014 - 12/2011)

Related Diseases

1.	Intestinal Neoplasms (Intestinal Cancer) 11/01/2017 - "In our previous study, sesquiterpenes β-caryophyllene oxide (CAO) and trans-nerolidol (NER) improved the anti-proliferative effect of doxorubicin (DOX) in intestinal cancer cell lines. " 08/21/2015 - "The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER), and valencene (VAL) are substantial components of the essential oil from Myrica rubra leaves which has exhibited significant antiproliferative effects in several intestinal cancer cell lines, with CaCo-2 cells being the most sensitive. "
2.	Breast Neoplasms (Breast Cancer) 11/01/2017 - "The effects of β-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice." 12/22/2011 - "In the present report, we investigated the effects of β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oils of medicinal plants such as guava (Psidium guajava), oregano (Origanum vulgare L.), cinnamon (Cinnamomum spp.) clove (Eugenia caryophyllata), and black pepper (Piper nigrum L.) on the PI3K/AKT/mTOR/S6K1 and MAPK activation pathways in human prostate and breast cancer cells. "
3.	Leukemia 08/01/2023 - "Results determined that the compounds D-limonene, α-pinene, and caryophyllene oxide were most potent against thyroid gland carcinoma (8505C) cells, brain glaucoma (Hs 683) cells, and promyeloblast leukemia (HL-60) cells, respectively. "
4.	Glaucoma 08/01/2023 - "Results determined that the compounds D-limonene, α-pinene, and caryophyllene oxide were most potent against thyroid gland carcinoma (8505C) cells, brain glaucoma (Hs 683) cells, and promyeloblast leukemia (HL-60) cells, respectively. "
5.	Colonic Neoplasms (Colon Cancer) 03/01/2019 - "Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Doxorubicin (Adriamycin)
3.	humulene
4.	nerolidol
5.	Fluorouracil (Carac)
6.	Limonene
7.	Oxaliplatin (Eloxatin)
8.	caryophyllene
9.	Volatile Oils (Essential Oils)
10.	Selective Estrogen Receptor Modulators (SERM)