koumine

08/09/2015 - "This study demonstrates that 3α-HSOR is an important molecular target of koumine for alleviating neuropathic pain. "
01/01/2023 - "Basolateral amygdala astrocytes modulate diabetic neuropathic pain and may be a potential therapeutic target for koumine."
09/01/2021 - "Koumine modulates spinal microglial M1 polarization and the inflammatory response through the Notch-RBP-Jκ signaling pathway, ameliorating diabetic neuropathic pain in rats."
01/01/2021 - "In summary, we have identified and characterized koumine as a TSPO PAM for the treatment of inflammatory and neuropathic pain. "
01/01/2018 - "We found that single or repeated treatment of koumine can significantly reduce neuropathic pain after nerve injury. "

07/15/2023 - "Koumine alleviates rheumatoid arthritis by regulating macrophage polarization."
01/01/2023 - "D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation."
12/15/2022 - "Regulation effect of koumine on T-helper cell polarization in rheumatoid arthritis."
01/01/2023 - "Koumine (KME) is the most abundant active ingredient separated from Gelsemium elegans Benth and exhibits a significant therapeutic effect on rheumatoid arthritis (RA). "
12/15/2022 - "Koumine, an alkaloid, exerts therapeutic effects against rheumatoid arthritis (RA), and thus may have a potential application in novel treatment strategies against this disease. "

11/01/2023 - "Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway."
01/01/2018 - "In addition, we found that koumine could decrease astrocyte-mediated neuroinflammation and enhance autophagy in primary cultured astrocytes. "
10/27/2017 - "The pharmacologic mechanism of koumine-mediated analgesia might involve inhibition of spinal neuroinflammation and activation of TSPO. "
01/01/2018 - "Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats."

01/01/2023 - "Koumine ameliorates concanavalin A-induced autoimmune hepatitis in mice: involvement of the Nrf2, NF-κB pathways, and gut microbiota."

01/01/2020 - "Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dose proportionality following oral administration in aged individuals remains unknown. "