rhinacanthin-C

isolated from Rhinacanthus nasutus; structure in first source

Also Known As:

3-(1-hydroxy-3,4-dioxo-3,4-dihydro-2-naphthalenyl)-2,2-dimethylpropyl (2E,6E)-2,6-dimethyl-2,6-octadienoate; rhinacanthin C

Networked: 17 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        rhinacanthin-C: 17
- Quinones: 434
  - Naphthoquinones: 418
    - rhinacanthin-C: 17
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - rhinacanthin-C: 17

Experts

1.	Panichayupakaranant, Pharkphoom: 5 articles (01/2021 - 01/2016)
2.	Shah, Muhammad Ajmal: 4 articles (01/2021 - 10/2017)
3.	Jianmongkol, Suree: 2 articles (01/2021 - 01/2017)
4.	Siripong, Pongpun: 2 articles (12/2018 - 01/2017)
5.	Sakagami, Hiroshi: 2 articles (01/2015 - 02/2013)
6.	Shirataki, Yoshiaki: 2 articles (01/2015 - 02/2013)
7.	Suzuki, Ryuichiro: 2 articles (01/2015 - 02/2013)
8.	Tomomura, Akito: 2 articles (01/2015 - 02/2013)
9.	Tomomura, Mineko: 2 articles (01/2015 - 02/2013)
10.	Ahmad, Bashir: 1 article (01/2021)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 01/01/2023 - "Rhinacanthin C Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways."
2.	Obesity 01/01/2018 - "Rhinacanthins-rich extract and its marker compounds showed potent glucose uptake stimulatory activity in 3T3-L1 adipocytes and L6 myotubesRhinacanthins-rich extract and rhinacanthin-C showed comparable antiadipogenic effect in 3T3-L1 adipocytesRRE could be used as an effective remedy in the treatment of obesity-associated T2DM. "
3.	Insulin Resistance 01/01/2023 - "Rhinacanthin C Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways."
4.	Hyperlipidemias (Hyperlipidemia) 01/15/2016 - "Effect of Rhinacanthin C on hyperglycaemia, hyperlipidemia and pancreatic dysfunction in diabetes was investigated. " 01/15/2016 - "Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin-nicotinamide induced adult male diabetic rats."
5.	Breast Neoplasms (Breast Cancer) 01/15/2017 - "In this study, we investigated an enhancement effect of rhinacanthin-C on doxorubicin cytotoxicity in human breast cancer cell lines and the involvement of the ABC drug efflux transporters. " 01/01/2021 - "Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells." 01/15/2017 - "Rhinacanthin-C enhances doxorubicin cytotoxicity via inhibiting the functions of P-glycoprotein and MRP2 in breast cancer cells."

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Niacinamide (Nicotinamide)
3.	Sirtuin 1
4.	Sterol Regulatory Element Binding Protein 1
5.	Lipids
6.	Glucose (Dextrose)
7.	Doxorubicin (Adriamycin)
8.	Naphthoquinones
9.	Esters
10.	rhinacanthin-D

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)