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zopiclone (Zop)

S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007

Also Known As:

Zop; Imovane; Zimovane; Limovan; Optidorm; Rhovane; Siaten; Somnosan; Ximovan; Zileze; Zimoclone; Zopi-Puren; Zopicalm; Zopicalma; Zopitan; Zorclone; zopiclodura; 6-(5-chloro-2-pyridyl)-6,7-dihydro- 7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1- piperazinecarboxylate; AbZ brand of zopiclone; Aliud brand of zopiclone; Alpharma brand of zopiclone; Aventis Pharma brand of zopiclone; Aventis brand of zopiclone; Azupharma brand of zopiclone; Ciclum brand of zopiclone; Clonmel brand of zopiclone; Dolorgeit brand of zopiclone; Gerard brand of zopiclone; Hexal brand of zopiclone; Hormosan brand of zopiclone; Italfarmaco brand of zopiclone; Merck dura brand of zopiclone; Norton brand of zopiclone; Nu-Pharm brand of zopiclone; Nu-Zopiclone; Opus brand of zopiclone; Pinewood brand of zopiclone; RP 27 267; Ratiopharm brand of zopiclone; Rhodiapharm brand of zopiclone; Rhône-Poulenc Rorer brand of zopiclone; Stadapharm brand of zopiclone; TAD brand of zopiclone; Temmler brand of zopiclone; Teva brand of zopiclone; Zopiclon AL; Zopiclon AZU; Zopiclon AbZ; Zopiclon Stada; Zopiclon TAD; Zopiclon beta; Zopiclon-TEVA; Zopiclon-neuraxpharm; Zopiclon-ratiopharm; betapharm brand of zopiclone; ct-Arzneimittel brand of zopiclone; neuraxpharm brand of zopiclone; ratio-Zopiclone; zopiclon von ct; 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester

Networked: 193 relevant articles (16 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Omvik, Siri: 3 articles (08/2009 - 06/2006)
2.	Nordhus, Inger Hilde: 3 articles (08/2009 - 06/2006)
3.	Pallesen, Ståle: 3 articles (08/2009 - 06/2006)
4.	Bjorvatn, Bjørn: 3 articles (08/2009 - 06/2006)
5.	Sivertsen, Børge: 3 articles (08/2009 - 06/2006)
6.	Gunja, Naren: 2 articles (06/2013 - 06/2013)
7.	Buchbinder, Rachelle: 2 articles (09/2012 - 01/2012)
8.	Richards, Bethan L: 2 articles (09/2012 - 01/2012)
9.	Whittle, Samuel L: 2 articles (09/2012 - 01/2012)
10.	Gustavsen, Ingebjørg: 2 articles (05/2012 - 08/2011)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 04/01/1990 - "In conclusion, zopiclone appears to be an effective and well-tolerated hypnotic that may play a role in the treatment of insomnia in the general population." 08/01/1996 - "In contrast, the sleep EEG data demonstrated the hypnotic efficacy of zopiclone under acute administration and indicated a rebound insomnia after abrupt discontinuation. " 08/01/1994 - "The efficacy of Zopiclone was studied in a group of patients with insomnia (n = 40). " 08/15/2009 - "This study suggests that the sleep of chronic users of zopiclone is no better than that of drug-free patients with insomnia. " 11/01/2002 - "[Study of the real situation of improvement by Zopiclone in treatment of insomnia among persons working during night shifts]."
2.	Pain (Aches) 01/01/1998 - "Patients in the zopiclone group had subjective improvement of sleep, but otherwise no differences in pain score or the other clinical parameters were found. " 06/01/1993 - "dolorimeter assessment of widespread tenderness, visual analogue scales and pain drawings for pain and other subjective feelings of discomfort, the effects of zopiclone treatment were at the same level as those of placebo." 06/01/1993 - "Effect of zopiclone on sleep quality, morning stiffness, widespread tenderness and pain and general discomfort in primary fibromyalgia patients. " 09/01/2012 - "The non-benzodiazepine agent zopiclone also did not significantly reduce pain over 2 weeks. " 01/01/2012 - "The non-benzodiazepine agent zopiclone also did not significantly reduce pain over two weeks. "
3.	Brain Injuries (Brain Injury) 01/01/2012 - "It is established that zopiclone exhibits pronounced hypnotic effect during the first and second week after brain injury, while nitrazepam, zolpidem, and melaxen are effective in the first week. " 06/01/2004 - "Comparison of lorazepam and zopiclone for insomnia in patients with stroke and brain injury: a randomized, crossover, double-blinded trial."
4.	Post-Traumatic Stress Disorders (PTSD) 10/01/2009 - "Overall, the results of this study suggest that, although the subjects in the follow-up phase of the research continued to use zopiclone on a regular basis for an extended period, the efficacy of this intervention for addressing PTSD-related sleep disturbance was low. " 10/01/2009 - "Further robust research to examine the consequences of long-term zopiclone therapy for PTSD-related sleep disturbance is warranted." 10/01/2009 - "We conducted a 6-month follow-up cohort study of zopiclone usage characteristics for 26 combat veterans with PTSD. " 10/01/2009 - "To examine the effects of the extended use of zopiclone among a cohort of patients with combat-related PTSD. " 10/01/2009 - "A qualitative investigation of long-term zopiclone use and sleep quality among Vietnam war veterans with PTSD."
5.	Delirium 09/01/2005 - "Zopiclone was resumed at a lower dose and delirium resolved completely." 09/01/2005 - "Finally, a diagnosis of abrupt zopiclone withdrawal causing delirium was made. " 09/01/2005 - "Zopiclone withdrawal: an unusual cause of delirium in the elderly." 01/01/1998 - "[Zopiclone and delirium: a case report]." 12/01/2014 - "Examination of the amount of antipsychotics prescribed before, during and after delirium shows that there was a significant increase in use during the delirium (χ(2) = 17.512, df 8, p = 0.025) and decrease in z-hypnotics medication (zopiclone/zolpidem), (χ(2) = 20.114, df 4, p < 0.001), while benzodiazepines and antidepressants remained the same. "

Related Drugs and Biologics

1.	zolpidem (Ambien)
2.	Triazolam (Halcion)
3.	Nitrazepam (Serenade)
4.	Benzodiazepines
5.	Flunitrazepam (Rohypnol)
6.	Pentobarbital (Nembutal)
7.	Temazepam (Nocturne)
8.	Flurazepam (Dalmane)
9.	Midazolam (Versed)
10.	Trazodone (Trittico)

Related Therapies and Procedures

1.	Ambulatory Surgical Procedures (Outpatient Surgery)
2.	Oral Administration
3.	Palliative Care (Palliative Medicine)
4.	Anesthesia