HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

tedizolid phosphate

a prodrug of DA-7157; structure in first source
Also Known As:
DA 7218; DA-7218; DA7218; Sivextro; TR 701; TR-701; torezolid phosphate
Networked: 61 relevant articles (10 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Prokocimer, Philippe: 11 articles (07/2019 - 09/2012)
2. De Anda, Carisa: 9 articles (09/2022 - 02/2013)
3. Flanagan, Shawn: 5 articles (01/2019 - 09/2014)
4. Fang, Edward: 5 articles (01/2017 - 02/2013)
5. Chou, Margaret Z: 3 articles (11/2021 - 01/2021)
6. De Anda, Carisa S: 3 articles (11/2021 - 01/2021)
7. Sears, Pamela S: 3 articles (11/2021 - 01/2021)
8. Bradley, John S: 3 articles (01/2021 - 01/2016)
9. Kim, Jason Y: 3 articles (01/2021 - 01/2021)
10. Sandison, Taylor: 3 articles (07/2019 - 01/2017)

Related Diseases

1. Infections
2. Mycetoma
3. Body Weight (Weight, Body)
01/01/2017 - "Tedizolid phosphate was administered to rabbits at 6 mg/kg of body weight intravenously twice daily, which yielded values of the 24-h area under the concentration-time curve approximating those found in humans. "
07/01/2011 - "Mean doses of 37.6 and 66.9 mg/kg of body weight/day of TR-701/700 resulted in stasis and 1 log CFU/g decreases in bacterial densities, respectively, at 24 h, and mean doses of 35.3, 46.6, and 71.1 mg/kg/day resulted in stasis and 1 and 2 log CFU/g reductions, respectively, at 48 h. "
01/01/2022 - "In this cross-over trial, 14 male healthy volunteers underwent two treatment periods: (A) 200 mg of tedizolid phosphate once daily for 6 days (3 days orally and 3 days intravenously), followed by an intravenous bolus of 2 ng/kg body weight of LPS on the last treatment day; and (B) intravenous bolus of LPS (2 ng/kg body weight) without concomitant tedizolid treatment. "
09/01/2012 - "In mice infected systemically with a lethal inoculum of PRSP 1 h prior to a single administration of either antimicrobial, oral tedizolid phosphate was equipotent to linezolid (1 isolate) to 2-fold more potent than linezolid (3 isolates) for survival at day 7, with tedizolid phosphate 50% effective dose (ED(50)) values ranging from 3.19 to 11.53 mg/kg of body weight/day. "
01/01/2015 - "The in vivo efficacy of tedizolid phosphate (15 mg/kg body weight intravenous [i.v.] twice a day [b.i.d.]) was compared to those of vancomycin (30 mg/kg i.v. b.i.d.) and daptomycin (18 mg/kg i.v. once a day [q.d.]) in a rabbit model of aortic valve endocarditis (AVE) caused by methicillin-resistant S. "
4. Pneumonia (Pneumonitis)
5. Neutropenia

Related Drugs and Biologics

1. Oxazolidinones (2 Oxazolidone)
2. Linezolid (Zyvox)
3. tedizolid
4. tedizolid phosphate
5. Vancomycin
6. Prodrugs
7. Daptomycin
8. Penicillins (Penicillin)
9. Bacterial Proteins (Bacterial Protein)
10. Saline Solution

Related Therapies and Procedures

1. Therapeutics
2. Mechanical Ventilators (Ventilator)
3. Catheters