Multidrug Resistance-Associated Proteins

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.

Also Known As:

ATP-Binding Cassette, Sub-Family C Proteins; MOAT Protein; Multispecific Organic Anion Transport Proteins; Multispecific Organic Anion Transporter; ATP Binding Cassette, Sub Family C Proteins; Multidrug Resistance Associated Protein; Multidrug Resistance Associated Proteins; Resistance-Associated Protein, Multidrug; Multidrug Resistance-Associated Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Multidrug Resistance-Associated Proteins: 701
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Multidrug Resistance-Associated Proteins: 701
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Multidrug Resistance-Associated Proteins: 701
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Multidrug Resistance-Associated Proteins: 701

C elegans MRP-4 protein

Bio-Agent Context: Research Results