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7-bromoindirubin-3'-oxime

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has mild protein kinase inhibitory activity; induces caspase-independent cell death; structure in first source

Also Known As:

7BIO cpd

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - 7-bromoindirubin-3'-oxime: 3
Organic Chemicals: 58
- Amines: 1422
  - Hydroxylamines: 10
    - Oximes: 320
      - 7-bromoindirubin-3'-oxime: 3

Experts

1.	Schenke, Susann: 1 article (01/2015)
2.	Broecker-Preuss, Martina: 1 article (01/2015)
3.	Rehmann, Katrin: 1 article (01/2015)
4.	Mann, Klaus: 1 article (01/2015)
5.	Gall, Susanne: 1 article (01/2015)
6.	Becher-Boveleth, Nina: 1 article (01/2015)
7.	Constantinou, Constantina: 1 article (08/2012)
8.	Liapis, Vasilis: 1 article (08/2012)
9.	Nicolaou, Katerina A: 1 article (08/2012)
10.	Koumas, Laura: 1 article (08/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/17/2012 - "The objective of the present study was to evaluate and compare the anticancer properties of the two novel bromo-substituted derivatives 6-bromoindirubin-3'-oxime (6BIO) and 7-bromoindirubin-3'-oxime (7BIO) in five different breast cancer cell lines. "
2.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2015 - "Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3'-oxime (7BIO)."
3.	Necrosis 08/01/2009 - "We identify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18. "

Related Drugs and Biologics

1.	6-bromoindirubin-3'-oxime
2.	indirubin
3.	Interleukin-18 (Interleukin 18)