Human immunodeficiency virus 1 p16 protease

Also Known As:

p16 protease, Human immunodeficiency virus 1; HIV-1 protease; p16 pol gene product, HIV-1; p16 pol gene product, Human immunodeficiency virus 1; p16 pol gene product, human immunodeficiency virus type 1; p16 protease, HIV-1

Networked: 266 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weber, Irene T: 10 articles (01/2020 - 05/2006)
2.	Ghosh, Arun K: 7 articles (01/2021 - 10/2006)
3.	Louis, John M: 6 articles (05/2020 - 05/2006)
4.	Das, Amit: 5 articles (05/2020 - 12/2006)
5.	Harrison, Robert W: 5 articles (01/2019 - 05/2006)
6.	Kovalevsky, Andrey Y: 5 articles (07/2013 - 05/2006)
7.	Prashar, Vishal: 5 articles (11/2009 - 07/2005)
8.	Hosur, M V: 5 articles (11/2009 - 06/2002)
9.	Kovalevsky, Andrey: 4 articles (02/2022 - 01/2017)
10.	Blakeley, Matthew P: 4 articles (05/2020 - 07/2013)

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2005 - "HIV-1 protease inhibitors had an immediate and dramatic impact on the outcome of HIV/AIDS when launched in late 1995, and the search for new and improved next generation molecules has been under way in many laboratories. " 01/01/2016 - "Many studies have targeted HIV-1 protease for the development of drugs against AIDS. " 12/01/2015 - "Several studies have focused on HIV-1 protease for developing drugs for treating AIDS. " 02/01/2015 - "Overall, this study aids in the understanding of the structural dynamics basis of drug resistance and evolutionary optimization in the HIV-1 protease system. " 12/20/2005 - "The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. "
2.	Infections 01/01/2019 - "NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal." 01/01/2014 - " of multiple infections was done using a previously published RFLP assay for the HIV-1 protease gene, which is able of distinguishing between infections caused by a single or multiple HIV-1 subtypes. " 01/01/2014 - "Analysis of HIV-1 protease gene reveals frequent multiple infections followed by recombination among drug treated individuals living in São Paulo and Santos, Brazil." 11/01/2011 - "Analysis of replicating viruses from a single round of infection identified 50 amino acid substitutions at 35 HIV-1 protease residue positions. " 10/01/2006 - "The replication of HIV-1 in these cells was also reduced as shown by quantification of the HIV-1 protease gene 24 h post-infection. "
3.	HIV Infections (HIV Infection) 02/09/2023 - "HIV-1 protease is an important target for pharmaceutical intervention in HIV infection. " 01/01/2021 - "Understanding the substrate specificity of HIV-1 protease plays an essential role in the prevention of HIV infection. " 01/01/2014 - "The dynamics of HIV-1 protease (HIV-pr), a drug target for HIV infection, has been studied extensively by both computational and experimental methods. " 05/15/2008 - "HIV-1 protease has been an important drug target for the antiretroviral treatment of HIV infection. " 01/01/2005 - "The efficacy of HIV-1 protease inhibitors (PIs) as part of highly active antiretroviral therapy is now well established and has provided benefits to many patients with HIV infection. "
4.	Insulinoma 01/01/2022 - "HIV-1 protease inhibitor is effective in the treatment of insulinoma in rats. " 01/01/2022 - "This study is aimed at investigating the treatment effectiveness of HIV-1 protease inhibitor for rats with insulinoma and its effects on interleukin-1β (IL-1β) and interleukin-18 (IL-18). " 01/01/2023 - "Retracted: Effect of HIV-1 Protease Inhibitor on IL-18 and IL-1β in Rats with Insulinoma." 01/01/2022 - "Effect of HIV-1 Protease Inhibitor on IL-18 and IL-1β in Rats with Insulinoma." 01/01/2004 - "To investigate whether HIV-1 protease inhibitor nelfinavir alters the insulin stimulated phosphorylation of insulin signaling parameters in rat insulinoma INS-1 cells. "
5.	HTLV-I Infections (HTLV-I Infection) 12/15/1998 - "The data suggested that the substrate binding site of HTLV-I protease is different from the substrate binding sites of pepsin and HIV-1 protease, and that currently employed HIV-1 protease inhibitors would not be effective for the treatment of HTLV-I infections."

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Antiviral Agents (Antivirals)
3.	Enzymes
4.	Pepsin A (Pepsin)
5.	Nelfinavir (Viracept)
6.	Ritonavir (Norvir)
7.	Proteins (Proteins, Gene)
8.	Indinavir (Crixivan)
9.	Atazanavir Sulfate (Reyataz)
10.	Interleukin-18 (Interleukin 18)

Related Therapies and Procedures

1.	Therapeutics
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Immunotherapy
4.	Photochemotherapy (Photodynamic Therapy)
5.	Combination Drug Therapy (Combination Chemotherapy)