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Human immunodeficiency virus 1 p31 integrase protein

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Also Known As:

p31 integrase protein, Human immunodeficiency virus 1; HIV-1 integrase; p31 pol gene Product, HIV I; p31 pol gene product, Human immunodeficiency virus 1; p31 pol gene product, human immunodeficiency virus type 1

Networked: 90 relevant articles (1 outcomes, 5 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Neamati, Nouri: 14 articles (11/2012 - 05/2004)
2.	Pommier, Yves: 7 articles (06/2014 - 09/2008)
3.	Marchand, Christophe: 5 articles (06/2014 - 09/2008)
4.	Zhao, Xue Zhi: 5 articles (06/2014 - 01/2009)
5.	Métifiot, Mathieu: 5 articles (06/2014 - 10/2011)
6.	Debyser, Zeger: 4 articles (11/2014 - 03/2004)
7.	Hughes, Stephen H: 4 articles (06/2014 - 10/2011)
8.	Smith, Steven J: 4 articles (06/2014 - 10/2011)
9.	Burke, Terrence R: 4 articles (06/2014 - 01/2009)
10.	Sanchez, Tino: 4 articles (04/2009 - 05/2004)

Related Diseases

1.	Infection 11/15/2005 - "Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3'-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-beta-gal-CD4+ cells." 07/01/2014 - "Dolutegravir (Tivicay(®)) is a new-generation HIV-1 integrase strand transfer inhibitor recently approved in the EU and Japan for the treatment of HIV-1 infection in adolescents and adults in combination with other antiretroviral drugs. " 01/01/2014 - "In last few years quite, a few but potent inhibitors inhibiting HIV-1 integrase have been recognized and hence have gained a state-of-the-art for treating the infection caused by HIV-1. " 10/16/2012 - "HIV-1 integrase strand transfer inhibitors are an important class of compounds targeted for the treatment of HIV-1 infection. " 01/01/2012 - "To identify novel factors involved in HIV-1 replication, HIV-1 integrase and matrix protein complexes were captured at 4 hours post infection for proteomic analysis using an affinity purification system. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/2010 - "Our study will be of help to identify the pharmacophores of inhibitors binding to HIV-1 integrase and design new pharmaceuticals for the treatment of AIDS." 12/01/2014 - "X-ray crystallography furthermore elucidated the mechanism of action of HIV-1 integrase strand transfer inhibitors, which are currently used to treat AIDS patients, and provided valuable insights into the mechanisms of viral drug resistance. " 06/26/2014 - "There are currently three HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) approved by the FDA for the treatment of AIDS. " 06/01/2013 - "HIV-1 integrase is an important therapeutic target in the fight against HIV/AIDS. " 07/23/2012 - "HIV-1 integrase (HIV-1 IN) is a recently validated biological target for AIDS therapy. "
3.	HIV Infections (HIV Infection) 01/01/2010 - "The paper presents the data of an investigation of the polymorphism of the pol gene encoding HIV-1 integrase in a HIV subtype G infected population formed during the 1989 HIV-infection outbreak. " 01/01/2010 - "[Analysis of HIV-1 integrase gene polymorphism in an HIV-infected population from the nosocomial outbreak of HIV infection in the south of Russia in 1989]." 02/24/2003 - "HIV-1 integrase is a novel therapeutic target and is the focus of efforts to identify effective inhibitors that will prevent/or cure HIV infections. " 05/06/2004 - "Discovery of diketoacid-containing compounds as HIV-1 integrase (IN) inhibitors played a major role in validating this enzyme as an important target for the development of therapeutics against HIV infection. " 03/01/2011 - "Since there is no human homolog of this enzyme, HIV-1 integrase (IN) represents a rational and important target for treating HIV infection and preventing AIDS. "
4.	Neoplasms (Cancer) 12/15/2008 - "Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines." 11/26/2012 - "Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties." 10/15/2011 - "Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells." 10/01/2002 - "Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. " 11/12/1999 - "Glycosylase/ap lyase activity explains MAP30's apparent inhibition of the HIV-1 integrase, MAP30's ability to irreversibly relax supercoiled DNA, and may be an alternative cytotoxic pathway that contributes to MAP30's anti-HIV/anti-tumor activities. "
5.	Viremia 03/15/2010 - "Intensification of antiretroviral therapy with a potent HIV-1 integrase inhibitor did not decrease persistent viremia in subjects receiving suppressive regimens, indicating that rapidly cycling cells infected with HIV-1 were not present. " 10/01/2011 - "Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. "

Related Drugs and Biologics

1.	MK 0518
2.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
3.	JTK 303
4.	Rilpivirine (TMC-278)
5.	DNA (Deoxyribonucleic Acid)
6.	Enzymes
7.	Complementary DNA (cDNA)
8.	Viral DNA
9.	Carbon Monoxide
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Highly Active Antiretroviral Therapy (HAART)