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technetium 99m ethylenedicysteine-metronidazole

used to image tumor hypoxia; structure in first source

Also Known As:

99mTc-EC-MN

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - Metronidazole: 6448
      - technetium 99m ethylenedicysteine-metronidazole: 2
- Organometallic Compounds: 64
  - Organotechnetium Compounds: 1
    - technetium 99m ethylenedicysteine-metronidazole: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        Metronidazole: 6448
        technetium 99m ethylenedicysteine-metronidazole: 2

Experts

1.	Bom, Hee-Seung: 1 article (04/2003)
2.	Cho, Ki Hyun: 1 article (04/2003)
3.	Kim, Byeong Chae: 1 article (04/2003)
4.	Kim, Chang-Guhn: 1 article (04/2003)
5.	Kim, E Edmund: 1 article (04/2003)
6.	Seo, Jeong-Jin: 1 article (04/2003)
7.	Song, Ho-Chun: 1 article (04/2003)
8.	Yang, David J: 1 article (04/2003)

Related Diseases

1.	Neoplasms (Cancer) 05/01/1999 - "Planar images and autoradiograms confirmed that the tumors could be visualized clearly with 99mTc-EC-MN from 0.5 to 4 hrs. There was no significant difference of tumor-to-blood count ratios between 99mTc-EC-MN and [(131)I]IMISO at 2 and 4 hrs postinjection. "
2.	Infarction (Infarctions) 04/01/2003 - "The infarct volumes from 99mTc-ECD images (IV(ECD)), infarct volumes from diffusion-weighted MRI images (IV(DW)), and hypoxic volume (HV) from 99mTc-EC-MN images were calculated. "
3.	Breast Neoplasms (Breast Cancer) 05/01/1999 - "Tissue distribution of 99mTc-EC-MN was determined in breast tumor-bearing rats at 0.5, 2, and 4 hrs. Planar imaging and whole-body autoradiograms were performed. "
4.	Ischemic Stroke 04/01/2003 - "Eight patients with acute ischemic stroke in the territory of the left middle cerebral artery underwent 99mTc-EC-MN and 99mTc-ethyl cysteinate dimer (ECD) brain SPECTs on the same day during the subacute stage (10.3+/-2.5 days). " 04/01/2003 - "99mTc-EC-MN brain SPECT can detect hypoxic tissue after acute ischemic stroke and, in combination with 99mTc-ECD brain SPECT, is useful in predicting neurological outcome in ischemic stroke patients."

Related Drugs and Biologics

1.	technetium Tc 99m bicisate (Neurolite)