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NSC606985

induces apoptosis

Networked: 8 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Camptothecin: 2033
    - NSC606985: 8

Experts

1.	Zhu, Yuan-Shan: 6 articles (11/2017 - 05/2005)
2.	Chen, Guo-Qiang: 5 articles (11/2009 - 05/2005)
3.	Yu, Yun: 4 articles (06/2009 - 05/2005)
4.	Imperato-McGinley, Julianne: 3 articles (11/2017 - 01/2009)
5.	Tan, Chen: 2 articles (11/2017 - 01/2009)
6.	Wang, Guo: 2 articles (11/2017 - 08/2016)
7.	Wang, Xin: 2 articles (11/2017 - 08/2016)
8.	Wang, Li-Shun: 2 articles (11/2009 - 09/2007)
9.	Xia, Li: 2 articles (06/2009 - 09/2007)
10.	Cai, Jing-Jing: 1 article (11/2017)

Related Diseases

1.	Acute Promyelocytic Leukemia 11/01/2007 - "Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia."
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/15/2009 - "We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through proteolytic activation of protein kinase C delta (DeltaPKC-delta). " 09/01/2007 - "We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through proteolytic activation of protein kinase Cdelta. " 05/01/2005 - "In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhibits the proliferation without cell death in breakpoint cluster region-Abelson murine leukemia (bcr-abl) kinase-carrying leukemic K562 cells. "
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2017 - "Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells." 08/01/2016 - "Dissociation of NSC606985 induces atypical ER-stress and cell death in prostate cancer cells." 01/01/2009 - "In the present study, the effects and potential mechanisms of NSC606985 (NSC), a water-soluble camptothecin analog, in prostate cancer cells were investigated. " 11/01/2017 - "We have previously shown that NSC606985 (NSC), a camptothecin (CPT) analog, induced cell apoptosis via interacting with topoisomerase I (Topo I) in prostate cancer cells. "
4.	Ovarian Neoplasms (Ovarian Cancer) 06/18/2009 - "These results suggest that NSC606985 and its combination with CDDP present the therapeutic potential on ovarian cancer, and deserve further preclinical and clinical studies." 06/18/2009 - "Human ovarian cancer cell line COC1 cells were treated with different nanomolar of NSC606985 with or without CDDP, and cell growth and apoptosis were evaluated, respectively, by MTT assay and annexin-V assay on flow cytometry. " 06/18/2009 - "In the present study, we investigated the potential anti-human ovarian cancer effects of NSC606985, a novel and rarely studied camptothecin analog, and its combination with cisplatin (CDDP). " 06/18/2009 - "NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells."
5.	Leukemia 05/01/2005 - "In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhibits the proliferation without cell death in breakpoint cluster region-Abelson murine leukemia (bcr-abl) kinase-carrying leukemic K562 cells. "

Related Drugs and Biologics

1.	Camptothecin
2.	Phosphotransferases (Kinase)
3.	Cisplatin (Platino)
4.	Protein Kinase C-delta
5.	Annexin A5
6.	Proteins (Proteins, Gene)
7.	Protein Kinases (Protein Kinase)
8.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole

Related Therapies and Procedures

1.	Therapeutics