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N- (4- chlorophenyl)- N'- (2,2,6,6- tetramethylpiperidin- 4- yl)oxalamide

inhibits binding of gp120(HIV) to CD4; structure in first source

Also Known As:

NBD 556; NBD-556; NBD556

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Oxalates: 2497
        N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide: 2

Experts

1.	Freire, Ernesto: 2 articles (11/2008 - 09/2006)
2.	Madani, Navid: 2 articles (11/2008 - 09/2006)
3.	Ng, Danny: 2 articles (11/2008 - 09/2006)
4.	Schön, Arne: 2 articles (11/2008 - 09/2006)
5.	Smith, Amos B: 2 articles (11/2008 - 09/2006)
6.	Sodroski, Joseph: 2 articles (11/2008 - 09/2006)
7.	Brower, Evan T: 1 article (11/2008)
8.	Courter, Joel R: 1 article (11/2008)
9.	Huang, Chih-Chin: 1 article (11/2008)
10.	Kwon, Young Do: 1 article (11/2008)

Related Diseases

1.

09/12/2006 - "NBD-556 stimulates HIV-1 infection of CD4-negative, CCR5-expressing cells. "
11/12/2008 - "Studies of NBD-556 analogs and gp120 mutants suggest that (1) NBD-556 binds within the Phe 43 cavity, a highly conserved, functionally important pocket formed as gp120 assumes the CD4-bound conformation; (2) the NBD-556 phenyl ring projects into the Phe 43 cavity; (3) enhancement of CD4-independent infection by NBD-556 requires the induction of conformational changes in gp120; and (4) increased affinity of NBD-556 analogs for gp120 improves antiviral potency during infection of CD4-expressing cells."

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)