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technetium 99m NC 100692

binds alphavbeta3 integrin, among others; putative integrin receptor imaging agent for breast cancer

Also Known As:

99mTc-NC100692; technetium 99m NC-100692; technetium 99m NC100692

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - technetium 99m NC 100692: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - technetium 99m NC 100692: 5
Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organotechnetium Compounds: 1
    - technetium 99m NC 100692: 5

Experts

1.	Sinusas, Albert J: 2 articles (01/2020 - 01/2019)
2.	Bach-Gansmo, Tore: 2 articles (02/2010 - 09/2006)
3.	Chan, Jefferson: 1 article (01/2020)
4.	Cole, John A: 1 article (01/2020)
5.	Dobrucki, Iwona T: 1 article (01/2020)
6.	Dobrucki, Lawrence W: 1 article (01/2020)
7.	Hedhli, Jamila: 1 article (01/2020)
8.	Huynh, Than: 1 article (01/2020)
9.	Insana, Michael F: 1 article (01/2020)
10.	Kalinowski, Leszek: 1 article (01/2020)

Related Diseases

1.	Infarction (Infarctions) 01/01/2019 - "In the infarct, sacubitril/valsartan induced an early uptake of 99mTc-NC100692 (a radiotracer of angiogenesis) and improved perfusion, as determined by 201Tl microSPECT/CT imaging. "
2.	Neoplasms (Cancer) 08/01/2013 - "Specific uptake of 99mTc-NC100692, an αvβ3-targeted imaging probe, in subcutaneous and orthotopic tumors." 02/01/2010 - "An open-label, multicenter, phase 2a study to assess the feasibility of imaging metastases in late-stage cancer patients with the alpha v beta 3-selective angiogenesis imaging agent 99mTc-NC100692."
3.	Neoplasm Metastasis (Metastasis) 02/01/2010 - "An open-label, multicenter, phase 2a study to assess the feasibility of imaging metastases in late-stage cancer patients with the alpha v beta 3-selective angiogenesis imaging agent 99mTc-NC100692."
4.	Ischemia 01/01/2020 - "Methods: In order to study the spatiotemporal dynamics of both perfusion and neovascularization in mice subjected to surgically-induced hindlimb ischemia (n= 30), we employed three label-free imaging modalities (a novel high-sensitivity ultrasonic Power Doppler methodology, laser speckle contrast, and photoacoustic imaging), as well as a tandem of radio-labeled molecular probes, 99mTc-NC100692 and 99mTc-BRU-5921 respectively, designed to detect two key modulators of angiogenic activity, αVβ3 and HIF-1α , via scintigraphic imaging. "
5.	Breast Neoplasms (Breast Cancer) 09/01/2006 - "Integrin receptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692."

Related Drugs and Biologics

1.	sacubitril and valsartan sodium hydrate drug combination
2.	Molecular Probes (Molecular Probe)
3.	N 30
4.	Integrins

Related Therapies and Procedures

1.	Lasers (Laser)