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(2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline)

prostacyclin (prostanoid IP) receptor antagonist

Also Known As:

CAY 10441; CAY-10441; CAY10441; RO1138452

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        (2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline): 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - (2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline): 5

Experts

1.	Hara, Shuntaro: 1 article (10/2021)
2.	Kuwata, Hiroshi: 1 article (10/2021)
3.	Ochiai, Tsubasa: 1 article (10/2021)
4.	Sasaki, Yuka: 1 article (10/2021)
5.	Yokoyama, Chieko: 1 article (10/2021)
6.	Baranowska-Kuczko, Marta: 1 article (01/2020)
7.	Kasacka, Irena: 1 article (01/2020)
8.	Kloza, Monika: 1 article (01/2020)
9.	Kozłowska, Hanna: 1 article (01/2020)
10.	Kozłowski, Mirosław: 1 article (01/2020)

Related Diseases

1.	Hyperalgesia 02/01/2014 - "The specific IP antagonist Cay10441 was applied intrathecally after zymosan-induced mechanical hyperalgesia in vivo. " 02/01/2006 - "RO1138452 (3-100 mg kg(-1), p.o.) and RO3244794 (0.3-30 mg kg(-1), p.o.) significantly reduced carrageenan-induced mechanical hyperalgesia and edema formation. "
2.	Overweight 01/01/2020 - "In hPAs, it was insensitive to antagonists of CB1 (AM251) and CB2 (AM630) receptors but it was reduced by endothelium denudation, cyclooxygenase inhibitors (indomethacin and nimesulide), antagonists of prostanoid EP4 (L161982), IP (Cay10441), vanilloid TRPV1 (capsazepine) receptors and was less potent under KCl-induced tone and calcium-activated potassium channel (KCa) inhibitors (iberiotoxin, UCL1684 and TRAM-34) and in hypertensive, overweight and hypercholesteremic patients. "
3.	Edema (Dropsy) 02/01/2006 - "RO1138452 (3-100 mg kg(-1), p.o.) and RO3244794 (0.3-30 mg kg(-1), p.o.) significantly reduced carrageenan-induced mechanical hyperalgesia and edema formation. "
4.	Cystitis 10/01/2021 - "Treatment with RO1138452, an IP selective antagonist, also suppressed CP-induced cystitis. "
5.	Hemorrhagic Cystitis 01/01/2019 - "Hemorrhagic cystitis reduced both ACh and EFS responses as well as the potentiatory effect of iloprost and the inhibitory effect of RO1138452 on ACh contractions. "

Related Drugs and Biologics

1.	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
2.	Cyclooxygenase Inhibitors
3.	Iloprost (Ventavis)
4.	Zymosan
5.	Prostaglandins
6.	Indomethacin (Indometacin)
7.	Carrageenan
8.	RO3244794
9.	L-161982
10.	TRAM 34