4- acetoxy- 5- (1- (naphthyl))naphtho(2,3- b)pyrrolo(2,1- d)(1,4)oxazepine

08/15/2013 - "PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines."

02/15/2011 - "Clonogenic assays were used to determine sensitivity of a panel of cancer cell lines (22Rv1, A549, U87) to PBOX-15 alone or in combination with a single 2Gy dose fraction. "
02/15/2011 - "We proposed to investigate the radiosensitizing properties of PBOX-15, a novel microtubule-disrupting agent, in a panel of cancer cell lines. "
02/15/2011 - "Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro."
01/18/2011 - "Thus, PBOX-15 represents a promising agent, with a distinct mechanism of action, for the treatment of this malignancy."
04/01/2008 - "Novel microtubule-targeting effects of PBOX-15 can possibly open new horizons in the treatment of overactive inflammatory conditions as well as cancer and cancer metastatic spreading."

01/01/2013 - "Here, we demonstrate that PBOX-15 inhibits cell growth, and induces G2/M cell cycle arrest and apoptosis in both T-ALL and B-cell ALL (B-ALL) cells. "
01/01/2013 - "PBOX-15 interferes with the lateral mobility and clustering of integrins in both B-ALL and T-ALL cells. "

01/18/2011 - "PBOX-15 induces apoptosis and potentiates TRAIL-induced cell death in multiple myeloma cells. "
01/18/2011 - "PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells."

02/15/2011 - "PBOX-15 prevented onset of hypoxia-induced radioresistance in hypoxic prostate cells and reduced the surviving fraction of irradiated hypoxic cells to levels similar to those achieved under aerobic conditions. "