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1,3- bis(bis(pyridin- 2- ylmethyl)amino)propan- 2- ol

structure in first source

Also Known As:

bis-bisPMAP; phos-tag

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol: 11

Experts

1.	Kinoshita, Eiji: 3 articles (01/2019 - 01/2009)
2.	Kinoshita-Kikuta, Emiko: 3 articles (01/2019 - 01/2009)
3.	Koike, Tohru: 3 articles (01/2019 - 01/2009)
4.	Hasegawa, Masato: 2 articles (12/2021 - 02/2016)
5.	Kimura, Taeko: 2 articles (12/2021 - 02/2016)
6.	Murayama, Shigeo: 2 articles (12/2021 - 02/2016)
7.	Cui, Lin: 1 article (01/2022)
8.	Jiang, Su: 1 article (01/2022)
9.	Li, Chen-Chen: 1 article (01/2022)
10.	Li, Yueying: 1 article (01/2022)

Related Diseases

1.	Ataxia Telangiectasia (Louis Bar Syndrome) 01/01/2009 - "In subsequent immunoblotting, phosphoisotypes of high-molecular-mass proteins, such as mammalian target of rapamycin (289 kDa), ataxia telangiectasia-mutated kinase (350 kDa) and p53-binding protein 1 (213 kDa), can be clearly detected as up-shifted migration bands on the improved Mn(2+)-Phos-tag SDS-PAGE gel. " 01/01/2017 - "This technique uses a dizinc(II) complex of the phosphate-binding molecule Phos-tag in conjunction with a neutral-pH gel system, Tris [tris(hydroxymethyl)aminomethane], and acetic acid (Tris-AcOH), to detect shifts in the mobility of phosphorylated ataxia telangiectasia-mutated (ATM) kinase. "
2.	Orthomyxoviridae Infections 12/05/2019 - "In this study, potential phosphorylation sites in the swine influenza virus (SIV) NS1 protein were bioinformatically predicted and determined by Phos-tag SDS-PAGE analysis. "
3.	Tauopathies 12/01/2021 - "Analysis of tau phosphorylation profiles using Phos-tag SDS-PAGE revealed distinct phosphorylation of tau in different tauopathies, whereas similar phosphorylation patterns were found within the same tauopathy. " 02/01/2016 - "The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method."
4.	Neoplasms (Cancer) 01/01/2022 - "Herein, we develop a phos-tag-based fluorescent biosensor for sensitive detection of cAMP-dependent protein kinase (PKA) activity in cancer cells. " 01/01/2022 - "Development of a phos-tag-based fluorescent biosensor for sensitive detection of protein kinase in cancer cells." 01/01/2019 - "By using Phos-tag affinity electrophoresis, we found that the introduction of mutations detected in certain sporadic cancers or in MEK-inhibitor-resistant cancer cells produced constitutively active MEK1 species containing phosphorylated Ser-218 and Ser-222 residues; it also enhanced the constitutive activity of the kinase. "
5.	Infections 11/01/2015 - "In planta, CpxAR is only activated at an early stage of the infection process as shown by Phos-Tag and gene fusion analyses. " 01/01/2021 - "Combined data illustrate the following: (i) infection kinetics of all three recombinant HCMVs, i.e., ORF-UL97 ∆231-255, ∆256-280 and ∆231-280, showed impaired replication efficiency compared to the wild type, amongst which the largest deletion exhibited the most pronounced defect; (ii) specifically, this mutant ∆231-280 showed a loss of interaction with cyclin T1, as demonstrated by CoIP and confocal imaging; (iii) IVKA and Phos-tag analyses revealed strongly affected kinase activity for ∆231-280, with strong impairment of both autophosphorylation and substrate phosphorylation, but less pronounced impairments for ∆231-255 and ∆256-280; and (iv) a bioinformatic assessment of the pUL97-cyclin T1 complex led to the refinement of our current binding model. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphotransferases (Kinase)
3.	TOR Serine-Threonine Kinases
4.	Phosphates (Orthophosphate)
5.	Cyclin T
6.	Mitogen-Activated Protein Kinase Kinases (MEKs)
7.	Acetic Acid (Vinegar)
8.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
9.	Tromethamine (Trometamol)
10.	Protein Kinases (Protein Kinase)