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talabostat

an antineoplastic agent; structure in first source
Also Known As:
L-valinyl-L-boroproline; PT 100; PT-100; PT100 cpd; valinyl-boroproline
Networked: 24 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jones, Barry: 5 articles (08/2011 - 09/2003)
2. Aziz, Nazneen: 2 articles (08/2011 - 06/2009)
3. Nemunaitis, John: 2 articles (07/2009 - 10/2006)
4. Adams, Sharlene: 2 articles (08/2004 - 09/2003)
5. Jesson, Michael I: 2 articles (08/2004 - 09/2003)
6. Miller, Glenn T: 2 articles (08/2004 - 09/2003)
7. Wallner, Barbara P: 2 articles (08/2004 - 09/2003)
8. Watanabe, Takeshi: 2 articles (08/2004 - 09/2003)
9. Fedorov, Alexey Yu: 1 article (01/2022)
10. Frias, Corazon: 1 article (01/2022)

Related Diseases

1. Neutropenia
2. Neoplasms (Cancer)
3. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
4. Melanoma (Melanoma, Malignant)
09/01/2007 - "In clinical trials, talabostat has demonstrated significant activity, including achieving complete responses in patients with non-small-cell lung cancer and malignant melanoma."
07/30/2009 - "Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma."
08/01/2004 - "Oral administration of PT-100 to mice slowed growth of syngeneic tumors derived from fibrosarcoma, lymphoma, melanoma, and mastocytoma cell lines. "
01/25/2022 - "In particular, the previously undescribed colchicinoid PT-100, a B-ring contracted 6-exo-methylene colchicinoid, exhibits extraordinarily high antiproliferative and apoptosis-inducing effects on various types of cancer cell lines like acute lymphoblastic leukemia (Nalm6), acute myeloid leukemia (HL-60), Burkitt-like lymphoma (BJAB), human melanoma (MelHO), and human breast adenocarcinoma (MCF7) cells at low nanomolar concentrations. "
12/01/2006 - "This issue focuses on the following selection of drugs: 5-Methyltetrahydrofolate, 9-aminocamptothecin; AdPEDF.11, AE-37, albumin interferon alfa, alicaforsen sodium, alvocidib hydrochloride, AMG-706, arginine butyrate, avanafil, axitinib, azimilide hydrochloride; BAY-579352, belagenpumatucel-L, beta-lapachone, BHT-3009, BIBW-2992, bremelanotide, BX-471; Casopitant mesylate, cediranib, certolizumab pegol, CH-1504, ChimeriVax-West Nile, clofazimine, CpG-7909, curcumin, Cypher; Dapoxetine hydrochloride, darusentan, diflomotecan, D-methionine, dnaJP1, D-serine, DTPw-HB Hib-MenAC, DTPw-HepB-Hib; E-7010, ecogramostim, edodekin alfa, EGFRvlll peptide vaccine, elcometrine, elcometrine/ethinylestradiol, elsilimomab, enrasentan, ertumaxomab, etalocib sodium, exisulind; Fenretinide, fesoterodine, fingolimod hydrochloride, fontolizumab; Gefitinib, gemtuzumab ozogamicin, ghrelin (human), GV-1001; HTU-PA, human papillomavirus vaccine; Indacaterol, indiplon, interleukin-21, intranasal insulin, irinotecan hydrochloride/floxuridine, ISIS-301012, ispinesib mesylate, ixabepilone; K562/GM-CSF; Lapatinib, L-BLP-25, linezolid, liposome encapsulated paclitaxel, LY-2124275; MC-1, MC-1/lisinopril, MDX-066, melanoma vaccine, MMR-V, multivalent (ACYW) meningitis vaccine; Nilotinib, nobori, nociceptin; Oblimersen sodium, orbofiban acetate, ospemifene; Paliperidone, panitumumab, PEG-filgrastim, PEGylated interferon alfacon-1, perflubutane, pertuzumab, phenserine tartrate, phVEGF-A165, pleconaril, prasugrel, prednisolone sodium metasulfobenzoate; R-411, recombinant malaria vaccine, rhGM-CSF, roflumilast, romidepsin, ruboxistaurin mesilate hydrate; Sirolimus-eluting stent, SR-4554, St. John's Wort extract; Talabostat, Taxus, TGN-255, tifacogin, tiotropium bromide, tolevamer sodium, trabectedin, tretinoin LF; Vatalanib succinate; Yellow fever vaccine, YM-155."
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Cytokines
2. Proteins (Proteins, Gene)
3. Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
4. Docetaxel (Taxotere)
5. Chemokines
6. Ghrelin
7. Papillomavirus Vaccines (HPV Vaccines)
8. Therapeutic Uses
9. Pertussis Toxin
10. Measles-Mumps-Rubella Vaccine (MMR Vaccine)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Vagus Nerve Stimulation
3. Stents
4. Electrodes (Electrode)
5. Oral Administration