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PHA-568487E

structure in first source

Also Known As:

N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide(2E)-2-butenedioate; PHA 568487; PHA-568487; PHA568487

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Dioxins and Dioxin-like Compounds: 5
  - Dioxins: 1199
    - PHA-568487E: 5
- Aza Compounds: 3
  - PHA-568487E: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxins: 1199
    - PHA-568487E: 5

Experts

1.	Su, Hua: 2 articles (01/2021 - 11/2014)
2.	Huang, Jinhao: 1 article (01/2021)
3.	Huo, Kang: 1 article (01/2021)
4.	Pan, Peipei: 1 article (01/2021)
5.	Prado, Leandro B Do: 1 article (01/2021)
6.	Shaligram, Sonali S: 1 article (01/2021)
7.	Wang, Zhanqiang: 1 article (01/2021)
8.	Wei, Meng: 1 article (01/2021)
9.	Wong, Julia: 1 article (01/2021)
10.	Zhang, Meng: 1 article (01/2021)

Related Diseases

1.	Neuroinflammatory Diseases 01/01/2018 - "The role played by α7 receptors on neuroinflammation was supported by the decrease of [18 F]DPA-714 binding in ischemic rats treated with the α7 agonist PHA 568487 at day 7 after MCAO. " 11/01/2014 - "Bone fracture at the acute stage of stroke exacerbates neuroinflammation, oxidative stress, and brain injury, and our study has shown that the α-7 nAchR agonist, PHA (PHA 568487), attenuates neuroinflammation, oxidative stress, and brain injury in mice with stroke and bone fracture. "
2.	Bone Fractures (Bone Fracture) 11/01/2014 - "Bone fracture at the acute stage of stroke exacerbates neuroinflammation, oxidative stress, and brain injury, and our study has shown that the α-7 nAchR agonist, PHA (PHA 568487), attenuates neuroinflammation, oxidative stress, and brain injury in mice with stroke and bone fracture. "
3.	Stroke (Strokes) 11/01/2014 - "Bone fracture at the acute stage of stroke exacerbates neuroinflammation, oxidative stress, and brain injury, and our study has shown that the α-7 nAchR agonist, PHA (PHA 568487), attenuates neuroinflammation, oxidative stress, and brain injury in mice with stroke and bone fracture. "
4.	Brain Injuries (Brain Injury) 11/01/2014 - "Bone fracture at the acute stage of stroke exacerbates neuroinflammation, oxidative stress, and brain injury, and our study has shown that the α-7 nAchR agonist, PHA (PHA 568487), attenuates neuroinflammation, oxidative stress, and brain injury in mice with stroke and bone fracture. "
5.	Cognitive Dysfunction 10/01/2014 - "Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia."

Related Drugs and Biologics

1.	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamide
2.	Risperidone (Risperdal Consta)
3.	Nicotinic Agonists
4.	Dizocilpine Maleate (Dizocilpine)
5.	Antipsychotic Agents (Antipsychotics)
6.	Cholinesterase Inhibitors (Anticholinesterases)
7.	Donepezil (Aricept)
8.	methyllycaconitine