DP 155

a mixture of 1-stearoyl- and 1-palmitoyl-2-(4-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetamido)butanoyl)-sn-glycero-3-phosphatidylcholine; reduces brain amyloid beta in Alzheimer's disease model; structure in first source

Also Known As:

DP-155; DP155 cpd

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Pharmaceutical Preparations
- Drug Combinations: 5337
  - DP 155: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indomethacin: 9574
        DP 155: 2
Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylcholines: 2371
        DP 155: 2

Experts

1.	Dahan, Arik: 1 article (01/2007)
2.	Duvdevani, Revital: 1 article (01/2007)
3.	Dvir, Eran: 1 article (01/2007)
4.	Elman, Anat: 1 article (01/2007)
5.	Friedman, Jonathan E: 1 article (01/2007)
6.	Hoffman, Amnon: 1 article (01/2007)
7.	Shapiro, Israel: 1 article (01/2007)
8.	Simmons, Danielle: 1 article (01/2007)
9.	Angel, I: 1 article (09/2006)
10.	Dahan, A: 1 article (09/2006)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2007 - "Moreover, DP-155 and indomethacin were equally efficacious in reducing levels of amyloid ss (Ass)42 in transgenic Alzheimer's disease mouse (Tg2576) brains as well as reducing Ass42 intracellular uptake, neurodegeneration, and inflammation in an in vitro AD model. " 01/01/2007 - "DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy." 09/01/2006 - "A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model."
2.	Stomach Ulcer (Gastric Ulcer) 01/01/2007 - "DP-155 did not produce gastric toxicity at the highest acute dose tested (0.28 mmol/kg), while indomethacin caused gastric ulcers at a dose 33-fold lower. "
3.	Inflammation (Inflammations) 01/01/2007 - "Moreover, DP-155 and indomethacin were equally efficacious in reducing levels of amyloid ss (Ass)42 in transgenic Alzheimer's disease mouse (Tg2576) brains as well as reducing Ass42 intracellular uptake, neurodegeneration, and inflammation in an in vitro AD model. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Lecithins
3.	Amyloid beta-Peptides
4.	Phospholipids (Phosphatides)
5.	Choline (Choline Chloride)
6.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia