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4- (5,6- dichloro- 1H- indol- 2- yl)- 3- ethoxy- N- (2,2,6,6- tetramethylpiperidin- 4- yl)benzamide

structure in first source

Also Known As:

Nik 12192; Nik-12192; Nik12192

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Croce, Anna Cleta: 2 articles (01/2008 - 09/2006)
2.	Farina, Carlo: 2 articles (01/2008 - 09/2006)
3.	Misiano, Paola: 2 articles (01/2008 - 09/2006)
4.	Petrangolini, Giovanna: 2 articles (01/2008 - 09/2006)
5.	Pratesi, Graziella: 2 articles (01/2008 - 09/2006)
6.	Supino, Rosanna: 2 articles (01/2008 - 09/2006)
7.	Tortoreto, Monica: 2 articles (01/2008 - 09/2006)
8.	Zunino, Franco: 2 articles (01/2008 - 09/2006)
9.	Bo, Laura Dal: 1 article (01/2008)
10.	Bottiroli, Giovanni: 1 article (01/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2006 - "The potentiation of topotecan efficacy by NiK-12192 was documented by an increased efficacy of the combination in both the HT29 tumor xenografts, being more evident in the topotecan-resistant HT29/Mit tumor. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2008 - "Oral administration of NiK-12192 caused a significant inhibition of formation of spontaneous metastases. " 01/01/2008 - "In this study, we used an indole derivative, NiK-12192 [4-(5,6-dichloro-1H-indol-2-yl)-3-ethoxy-N-(2,2,6,6-tetramethyl-piperidin-4-yl)-benzamide], recently identified as an effective inhibitor of vacuolar H(+)-ATPase, as a potential antimetastatic agent in the treatment of NSCLC H460 xenograft, which is able to induce lung metastases in mice. "
3.	Carcinoma (Carcinomatosis) 09/01/2006 - "The cellular studies performed in two pairs of human colon carcinoma cell lines, i.e., LoVo and LoVo/DX (overexpressing P-glycoprotein) and HT29 and HT29/Mit (overexpressing breast cancer resistant protein), indicated an enhancement of the antiproliferative effect of camptothecins by concomitant exposure to subtoxic concentrations of NiK-12192. "
4.	Breast Neoplasms (Breast Cancer) 09/01/2006 - "The cellular studies performed in two pairs of human colon carcinoma cell lines, i.e., LoVo and LoVo/DX (overexpressing P-glycoprotein) and HT29 and HT29/Mit (overexpressing breast cancer resistant protein), indicated an enhancement of the antiproliferative effect of camptothecins by concomitant exposure to subtoxic concentrations of NiK-12192. "

Related Drugs and Biologics

1.	Topotecan (Hycamtin)
2.	Vacuolar Proton-Translocating ATPases (V-Type ATPase)
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	Proteins (Proteins, Gene)
5.	benzamide
6.	indole

Related Therapies and Procedures

1.	Oral Administration