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RS-130830

orally-active broad-spectrum matrix metalloproteinase inhibitor

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - RS-130830: 2
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - RS-130830: 2

Experts

1.	Bächtold, Fabian: 1 article (03/2015)
2.	Grandgirard, Denis: 1 article (03/2015)
3.	Leib, Stephen L: 1 article (03/2015)
4.	Leppert, David: 1 article (03/2015)
5.	Liechti, Fabian D: 1 article (03/2015)
6.	Behrendt, Margareta: 1 article (08/2006)
7.	Elebring, Marie: 1 article (08/2006)
8.	Fritsche-Danielson, Regina: 1 article (08/2006)
9.	George, Sarah J: 1 article (08/2006)
10.	Herslof, Margareta: 1 article (08/2006)

Related Diseases

1.	Brain Injuries (Brain Injury) 03/04/2015 - "This study identifies MMP inhibition, specifically with RS-130830, as an efficient strategy to attenuate disease severity and cortical brain injury in PM." 03/04/2015 - "The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis."
2.	Arthritis (Polyarthritis) 03/04/2015 - "RS-130830 (Ro-1130830, CTS-1027) is a potent partially selective inhibitor of MMPs of a second generation and has been evaluated in clinical trials as an anti-arthritis drug. "
3.	Atherosclerosis 08/01/2006 - "These data suggest that broad-spectrum MMP inhibition RS-130830 does not have a beneficial effect on atherosclerosis in the apolipoprotein E knockout mouse model, and indicate that more selective compounds would be preferable."
4.	Weight Loss (Weight Reduction) 03/04/2015 - "RS-130830 significantly reduced weight loss and leukocyte counts in the cerebrospinal fluid of survivors of PM. "
5.	Necrosis 03/04/2015 - "Cortical necrosis was significantly attenuated in animals treated with RS-130830, while the extent of hippocampal apoptosis was not influenced. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Matrix Metalloproteinase Inhibitors
3.	Apolipoproteins