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biotin-BSA-GdDTPA

contrast media

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dekel, Nava: 1 article (05/2006)
2.	Kalchenko, Vyacheslav: 1 article (05/2006)
3.	Neeman, Michal: 1 article (05/2006)
4.	Plaks, Vicki: 1 article (05/2006)
5.	Granot, D: 1 article (10/2005)
6.	Kunz-Schughart, L A: 1 article (10/2005)
7.	Neeman, M: 1 article (10/2005)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2005 - "This study shows that labeling of fibroblasts with biotin-BSA-GdDTPA-FAM is feasible and would allow noninvasive in vivo tracking of fibroblasts during tumor angiogenesis and vessel maturation." 10/01/2005 - "Labeling fibroblasts with biotin-BSA-GdDTPA-FAM for tracking of tumor-associated stroma by fluorescence and MR imaging." 10/01/2005 - "After intravenous administration of biotin-BSA-GdDTPA-FAM in mice with subcutaneous MLS human ovarian carcinoma tumors, the distribution of the macromolecular MRI/optical contrast material was confined to blood vessels in normal tissues, while it co-registered with alphaSMA-positive stroma tracks within the tumor. "
2.	Vascular Remodeling 05/01/2006 - "Here we show that contrast-enhanced (CE)-MRI and fluorescence microscopy using biotin-BSA-GdDTPA allowed high-resolution detection and quantitative assessment of mouse embryo implantation sites as early as embryonic day 4.5 (E4.5), and subsequent vascular expansion at E5.5. Vessel permeability, but not blood volume, was significantly elevated in E4.5 implantation sites relative to nonimplanted uterus, showing that elevation of vascular permeability is a very early response preceding E4.5. A significantly increased blood volume was detected by MRI and fluorescence microscopy in implantation sites between E4.5 and E5.5. On the other hand, despite the increase in blood volume, implantation sites showed only a small nonsignificant further increase in vascular permeability during these 2 days, demonstrating the rapid dynamics of vascular remodeling during the early days of pregnancy. "
3.	Carcinoma (Carcinomatosis) 10/01/2005 - "After intravenous administration of biotin-BSA-GdDTPA-FAM in mice with subcutaneous MLS human ovarian carcinoma tumors, the distribution of the macromolecular MRI/optical contrast material was confined to blood vessels in normal tissues, while it co-registered with alphaSMA-positive stroma tracks within the tumor. "

Related Drugs and Biologics

1.	Contrast Media

Related Therapies and Procedures

1.	Intravenous Administration