PNC-28

a p53-derived peptide from its mdm-2-binding domain (residues 17-26), which contains the penetratin sequence enabling cell penetration on its carboxyl terminal end; induces necrosis, but not apoptosis in a variety of human tumor cell lines; amino acid sequence in first source

Networked: 3 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Michl, Josef: 3 articles (01/2015 - 10/2006)
2.	Pincus, Matthew R: 3 articles (01/2015 - 10/2006)
3.	Bowne, Wilbur B: 2 articles (01/2015 - 12/2008)
4.	Sarafraz-Yazdi, Ehsan: 2 articles (01/2015 - 12/2008)
5.	Abulafia, Ovadia: 1 article (01/2015)
6.	Angert, Mallorie: 1 article (01/2015)
7.	Gartman, Charles H: 1 article (01/2015)
8.	Gorelick, Constantine: 1 article (01/2015)
9.	Gupta, Vinita: 1 article (01/2015)
10.	Lee, Yi-Chun: 1 article (01/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2006 - "These results suggest that PNC-28 may be effective in treating cancers especially if delivered directly to the tumor." 10/01/2006 - "When administered over a 2-week period in the peritoneal cavities of nude mice containing simultaneously transplanted tumors, PNC-28 causes complete destruction of these tumors. " 10/01/2006 - "When administered after tumor growth has occurred at a site remote from the tumor, PNC-28 causes a decrease in tumor size followed by a slow increase in tumor growth that is significantly slower than growth in the presence of control peptide. " 10/01/2006 - "When delivered concurrently with tumor explantation at a remote site, PNC-28 causes a complete blockade of any tumor growth during its 2-week period of administration and 2 weeks posttreatment, followed by weak tumor growth that plateaus at low tumor sizes compared with tumor growth in the presence of a control peptide. " 12/01/2008 - "Treatment with PNC-28 does not result in the elevation of proapoptotic proteins found in p53-induced apoptosis, but elicits rapid release of LDH, indicative of tumor cell necrosis. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2008 - "These results suggest that PNC-28 may be effective in treating human pancreatic cancer. " 12/01/2008 - "The anticancer activity and mechanism of PNC-28 (p53 aa17-26-penetratin) was specifically studied against human pancreatic cancer. " 10/01/2006 - "PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo." 12/01/2008 - "The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells."
3.	Necrosis 12/01/2008 - "Treatment with PNC-28 does not result in the elevation of proapoptotic proteins found in p53-induced apoptosis, but elicits rapid release of LDH, indicative of tumor cell necrosis. " 12/01/2008 - "Since there is evidence that penetratin is required for tumor cell necrosis, we tested "naked" p53 peptide without penetratin by transfecting a plasmid that encodes p53 aa17-26 segment of PNC-28 into MiaPaCa-2 and an untransformed rat pancreatic acinar cell line, BMRPA1. " 12/01/2008 - "The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	PNC-27
3.	Proteins (Proteins, Gene)
4.	penetratin