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INCB3619

ADAM inhibitor; structure in first source

Also Known As:

INCB 3619

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - INCB3619: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - INCB3619: 3
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - INCB3619: 3

Experts

1.	Caulder, Eian: 2 articles (09/2008 - 03/2007)
2.	Adhikari, Sarbani: 1 article (01/2017)
3.	Ayaloglu-Butun, Fatma: 1 article (01/2017)
4.	Bissonnette, Marc: 1 article (01/2017)
5.	Dougherty, Urszula: 1 article (01/2017)
6.	Fichera, Alessandro: 1 article (01/2017)
7.	Fletcher, Michelle: 1 article (01/2017)
8.	Haider, Haider I: 1 article (01/2017)
9.	Hart, John: 1 article (01/2017)
10.	Joseph, Loren: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/15/2017 - "In Min mice, INCB3619 reduced EGFR signals in adenomas and inhibited intestinal tumor multiplicity (P < 0.05). " 03/15/2007 - "Administration of INCB3619 to tumor-bearing mice reduced ErbB ligand shedding in vivo and inhibited ErbB pathway signaling (e.g., phosphorylation of Akt), tumor cell proliferation, and survival. " 03/15/2007 - "Further, INCB3619 synergized with clinically relevant cancer therapeutics and showed no overt or compounding toxicities, including fibroplasia, the dose-limiting toxicity associated with broad-spectrum matrix metalloprotease inhibitors. "
2.	Carcinogenesis 01/15/2017 - "Using Apc-mutant Min mice, we investigated the effects of ADAM17/10 inhibitor INCB3619 on tumorigenesis. "
3.	Breast Neoplasms (Breast Cancer) 09/01/2008 - "Combining INCB3619 with a lapatinib-like dual inhibitor of EGFR and HER-2/neu kinases resulted in synergistic growth inhibition in MCF-7 and HER-2/neu-transfected MCF-7 human breast cancer cells. "
4.	Adenoma (Adenomas) 01/15/2017 - "In Min mice, INCB3619 reduced EGFR signals in adenomas and inhibited intestinal tumor multiplicity (P < 0.05). "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Phosphotransferases (Kinase)
3.	Ligands
4.	Lapatinib (GW572016)

Related Therapies and Procedures

1.	Therapeutics