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7-deazapurine

structure in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - 7-deazapurine: 6

Experts

1.	Daelemans, Dirk: 1 article (01/2020)
2.	Herdewijn, Piet: 1 article (01/2020)
3.	Li, Qingfeng: 1 article (01/2020)
4.	Persoons, Leentje: 1 article (01/2020)
5.	Bistrović, Andrea: 1 article (12/2018)
6.	Grbčić, Petra: 1 article (12/2018)
7.	Harej, Anja: 1 article (12/2018)
8.	Koštrun, Sanja: 1 article (12/2018)
9.	Kraljević-Pavelić, Sandra: 1 article (12/2018)
10.	Makuc, Damjan: 1 article (12/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The cytotoxicity study of compounds 11a-q shows that by modifying the 6-position of 7-deazapurine ribonucleosides, the compounds may become selective for certain cancer cell lines." 09/01/2014 - "Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells." 01/01/2017 - "Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines and thieno[3',2':4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, nucleophilic azidation, and cyclization of tetrazolopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at position 4. Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer and leukemia cell lines and some antiviral activity against HCV. "
2.	Leukemia 01/01/2017 - "Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines and thieno[3',2':4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, nucleophilic azidation, and cyclization of tetrazolopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at position 4. Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer and leukemia cell lines and some antiviral activity against HCV. "
3.	Hepatocellular Carcinoma (Hepatoma) 12/01/1976 - "1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-(5-14C)-1-beta-D-ribofuranysly (NSC-154020), a tricyclic 7-deazapurine nucleoside (TCN), was rapidly incorporated into the acid-soluble pool by cultured Novikoff rat hepatoma cells, mouse L-cells, HeLa cells, and HEp-2 cells, but little incorporation into nucleic acids occurred. "
4.	Colonic Neoplasms (Colon Cancer) 12/01/2018 - "While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on pancreatic adenocarcinoma cells CFPAC-1,1-(p-fluorophenyl)-1,2,3-triazole derivative of 7-deazapurine showed selective cytostatic effect on metastatic colon cancer cells SW620. "
5.	Bites and Stings (Sting) 10/27/2022 - "Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists."

Related Drugs and Biologics

1.	Ribonucleosides
2.	Nucleosides
3.	Cytostatic Agents
4.	purine
5.	Pyrimidines
6.	Nucleic Acids
7.	Antiviral Agents (Antivirals)
8.	Adenosine (Adenocard)
9.	Acids