hypophyllanthin

Anti-inflammatory from Phyllanthus amarus

Also Known As:

(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho(1,2-d)(1,3)dioxole; Naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7R,8R,9S)-

Networked: 7 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        hypophyllanthin: 7

Experts

1.	Fuad Hafid, Achmad: 1 article (06/2021)
2.	Marhaeny, Honey Dzikri: 1 article (06/2021)
3.	Wahyuni, Tutik Sri: 1 article (06/2021)
4.	Widiandani, Tri: 1 article (06/2021)
5.	Widyawaruyanti, Aty: 1 article (06/2021)
6.	Jiao, Zelin: 1 article (02/2019)
7.	Li, Yinfang: 1 article (02/2019)
8.	Qin, Rui: 1 article (02/2019)
9.	Wang, Xiaohua: 1 article (02/2019)
10.	Wu, Wei: 1 article (02/2019)

Related Diseases

1.	Asthma (Bronchial Asthma) 02/01/2019 - "Thus, phyllanthin and hypophyllanthin may be a new therapeutic approach for the management of asthma." 02/01/2019 - "Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL's."
2.	Pain (Aches) 08/01/2015 - "The current study was aimed at evaluating the antihyperalgesic effects of lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich three standardized extracts of Phyllanthus amarus in a model of chronic musculoskeletal inflammatory pain. " 08/01/2015 - "Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan-induced Thermal and Mechanical Chronic Muscle Hyperalgesia."
3.	Neoplasms (Cancer) 01/01/2022 - "Several mechanisms of action on the effects of hypophyllanthin on the immune system, in cancer and other disease states, were presented to provide some insights into its pharmacological effects. " 01/01/2022 - "Studies conducted in vitro and in vivo showed that hypophyllanthin had potent immunomodulating properties as well as a variety of other pharmacological properties, including anti-inflammatory, hepatoprotective, anti-tumor, anti-allergic, anti-hypertensive, and phytoestrogenic properties. "
4.	Breast Neoplasms (Breast Cancer) 08/08/2023 - "The current work is aimed to study the potential cytotoxicity and chemomodulatory effects of hypophyllanthin (PN4) and phyllanthin (PN5) isolated from Phyllanthus niruri to DOX against the adriamycin multidrug-resistant breast cancer cells (MCF-7ADR) and elucidate their mechanism of action. " 08/08/2023 - "Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells."
5.	COVID-19 06/25/2021 - "Phyllanthin and hypophyllanthin demonstrated to possess greater binding affinity toward the COVID-19 inhibition sites than their native ligand. " 06/25/2021 - "In conclusion, phyllanthin and hypophyllanthin are predicted to have strong activity against COVID-19 through inhibiting spike glycoprotein and main protease under in silico study. " 06/25/2021 - "Therefore, in silico screening against COVID-19 receptors is carried out as an initial stage of drug discovery by evaluating the activity of phyllanthin and hypophyllanthin, an isolated from Phyllanthus niruri, in inhibiting spike glycoprotein (6LZG) and main protease (5R7Y) which play as target receptors of COVID-19. "

Related Drugs and Biologics

1.	phyllanthin
2.	Ovalbumin
3.	Immunoglobulin E (IgE)
4.	Lignans
5.	Anti-Allergic Agents (Antiallergic Agents)
6.	Tannins
7.	Peptide Hydrolases (Proteases)
8.	Glycoproteins (Glycoprotein)
9.	Doxorubicin (Adriamycin)
10.	Antihypertensive Agents (Antihypertensives)