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xestospongin C

was indexed to xestospongin A; from Xestospongia sponge; empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release

Also Known As:

XeC compound

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - xestospongin C: 12
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - xestospongin C: 12

Experts

1.	Angert, Mila: 1 article (01/2020)
2.	Chernov, Andrei V: 1 article (01/2020)
3.	Dolkas, Jennifer: 1 article (01/2020)
4.	Eddinger, Kelly A: 1 article (01/2020)
5.	Hullugundi, Swathi K: 1 article (01/2020)
6.	James, Brian P: 1 article (01/2020)
7.	Remacle, Albert G: 1 article (01/2020)
8.	Shubayev, Veronica I: 1 article (01/2020)
9.	Strongin, Alex Y: 1 article (01/2020)
10.	Yaksh, Tony L: 1 article (01/2020)

Related Diseases

1.	Hypertrophy 10/01/2005 - "The hypertrophy was abolished by U73122, xestospongin C (blockers of the 1,4,5-IP3 pathway), genistein and by the PI3K blocker LY294002. " 07/01/2006 - "More importantly, IP3R inhibitors, 2-aminoethoxydiphenyl borate and Xestospongin C, abolished the IP3BM-induced Ca2+ responses, and significantly suppressed alpha1AR-induced cardiomyocyte hypertrophy assayed by cell size, [3H] leucine incorporation and atrial natriuretic factor gene expression, during sustained (48 h) phenylephrine stimulation. "
2.	Hypoxia (Hypoxemia) 07/01/2012 - "The IP(3)R antagonist xestospongin C (XeC, 0.1 μM) blocked Ca(2+) release to norepinephrine and hypoxia but not caffeine. " 08/24/2012 - "Furthermore, we found that pretreatment with NaHS could significantly inhibit hypoxia-induced neuronal apoptosis, which was also inhibited by PEG-catalase or the inositol 1,4,5-triphosphate (IP(3)) receptor blocker xestospongin C. "
3.	Tetanus 07/01/2004 - "The LTP of quantal content produced by the conditioning tetanus was blocked by thapsigargin, a blocker of Ca(2+) pumps at Ca(2+) stores, applied before or after the conditioning tetanus, and by Xestospongin C, a blocker of inositoltrisphosphate (IP(3)) receptors, applied before the tetanus. "
4.	Neoplasms (Cancer) 12/01/2023 - "HERPUD1 knockdown increased intracellular Ca2+ release and mitochondrial Ca2+ influx, which was prevented using the ITPR3 antagonist xestospongin C or the Ca2+ chelator BAPTA-AM. Furthermore, HERPUD1 expression reduced tumor cell migration by controlling ITPR3-mediated Ca2+ signals. "
5.	Necrosis 01/01/2002 - "Moreover, xestospongin C, an inhibitor of endoplasmic reticulum Ca(2+) release, enhanced the capacity of NT2-N neurons to maintain [Ca(2+)](i) homeostasis and resist necrosis while subjected to sustained energy deprivation. "

Related Drugs and Biologics

1.	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)
2.	Phenylephrine (Neo-Synephrine)
3.	rho-Associated Kinases
4.	Genistein
5.	Thapsigargin
6.	Fura-2 (Fura 2)
7.	Inositol 1,4,5-Trisphosphate
8.	Norepinephrine (Noradrenaline)
9.	Atrial Natriuretic Factor (ANF)
10.	Leucine (L-Leucine)