HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

(N)-methanocarba-2MeSADP

a selective agonist of P2Y1 receptors

Also Known As:

MRS2365

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Diphosphate: 4554
        (N)-methanocarba-2MeSADP: 7
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Diphosphate: 4554
        (N)-methanocarba-2MeSADP: 7
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Diphosphate: 4554
        (N)-methanocarba-2MeSADP: 7

Experts

1.	Campbell, Mary: 1 article (12/2020)
2.	Gao, Zhan-Guo: 1 article (12/2020)
3.	Hinz, Sonja: 1 article (12/2020)
4.	Holstein, Deborah M: 1 article (12/2020)
5.	Jacobson, Kenneth A: 1 article (12/2020)
6.	Korinek, William S: 1 article (12/2020)
7.	Lechleiter, James D: 1 article (12/2020)
8.	Liston, Theodore E: 1 article (12/2020)
9.	Melton, Roger J: 1 article (12/2020)
10.	Müller, Christa E: 1 article (12/2020)

Related Diseases

1.	Stroke (Strokes) 12/01/2020 - "In vivo efficacy of MRS2365 in murine models of traumatic brain injury and stroke can be attributed to AR activation by its nucleoside metabolite AST-004, rather than P2Y1R activation. "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 12/01/2020 - "In vivo efficacy of MRS2365 in murine models of traumatic brain injury and stroke can be attributed to AR activation by its nucleoside metabolite AST-004, rather than P2Y1R activation. "
3.	Acute Pain 03/01/2010 - "The rank order of mED values in acute pain was the following: MRS2365 > MRS2395 > NF449 > NF023 > UDP = UTP > PPADS. "
4.	Wounds and Injuries (Trauma) 01/01/2013 - "Treatment of mice with 2MeSADP (100 μM) or MRS2365 (100 μM) 30 min after trauma significantly reduced all post-injury symptoms of TBI including edema, neuronal swelling, reactive gliosis, and AQ4 expression. "
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2023 - "The P2RY1 receptor activation in human SGC7901 gastric cancer cells via the MRS2365 agonist induced apoptosis and reduced cell growth. " 01/01/2023 - "The proliferation and apoptosis of the SGC7901 gastric cancer cell line were determined after treatment with a selective P2RY1 receptor agonist, MRS2365. "

Related Drugs and Biologics

1.	Nucleosides
2.	Purinergic P2Y Receptor Antagonists
3.	Purinergic P2X7 Receptors
4.	Purinergic P2X1 Receptors
5.	Purinergic P2Y1 Receptors
6.	Uridine Triphosphate (UTP)
7.	Uridine Diphosphate (UDP)
8.	Uridine
9.	Salts
10.	Diphosphates (Pyrophosphates)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)