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4- nitro- N- (1- (2- fluorophenyl)- 3- phenyl- 1H- pyrazol- 5- yl)benzamide

a metabotropic glutamate-5 receptor modulator; structure in first source

Also Known As:

VU 1545; VU-1545; VU1545

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Faden, Alan I: 1 article (01/2014)
2.	Hanscom, Marie: 1 article (01/2014)
3.	Kabadi, Shruti V: 1 article (01/2014)
4.	Stoica, Bogdan A: 1 article (01/2014)
5.	Xue, Fengtian: 1 article (01/2014)

Related Diseases

1.

Traumatic Brain Injuries (Traumatic Brain Injury)

01/01/2014 - "To address such concerns, we evaluated the anti-inflammatory activities of several positive allosteric modulators using various in vitro assays, and found that 3,3'-difluorobenzaldazine, 3-cyano-N-(1,3-diphenyl-1H-pyrazol- 5-yl)benzamide and 4-nitro-N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-5-yl)benzamide showed significantly improved potency which makes them potential lead compounds for further development of positive allosteric modulators for the treatment of traumatic brain injury."

Related Drugs and Biologics

1.	3,3'-difluorobenzaldazine