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2-amino-5-ureidopentanamide

neuroprotective agent isolated from Parawixia bistriata spider venom; structure in first source

Also Known As:

FrPbAII; parawixin 2, Parawixia bistriata; parawixin2, Parawixia bistriata

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Arthropod Venoms: 770
    - Spider Venoms: 129
      - 2-amino-5-ureidopentanamide: 3
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Arthropod Venoms: 770
      - Spider Venoms: 129
        2-amino-5-ureidopentanamide: 3
Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - 2-amino-5-ureidopentanamide: 3

Experts

1.	Coutinho-Netto, Joaquim: 3 articles (01/2007 - 06/2006)
2.	Cunha, Alexandra Olimpio Siqueira: 2 articles (01/2007 - 12/2006)
3.	Lopes, Norberto Peporine: 2 articles (01/2007 - 06/2006)
4.	dos Santos, Wagner Ferreira: 2 articles (01/2007 - 12/2006)
5.	Beleboni, Rene Oliveira: 1 article (01/2007)
6.	Gelfuso, Erica Aparecida: 1 article (01/2007)
7.	Liberato, Jose Luiz: 1 article (01/2007)
8.	Mortari, Marcia Renata: 1 article (01/2007)
9.	Paraventi, Karina Haddad: 1 article (01/2007)
10.	Beleboni, René de Oliveira: 1 article (12/2006)

Related Diseases

1.	Seizures (Absence Seizure) 12/08/2006 - "Interestingly, when microinjected bilaterally in the SNPr of freely moving rats, FrPbAII (0.6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0.75 microg/microl). " 01/16/2007 - "The anticonvulsant effect of FrPbAII differed from that of nipecotic acid in potency, as the doses needed to block the seizures were more than 10 folds lower. " 01/16/2007 - "Our results show that FrPbAII was effective against seizures induced by the i.c.v. injection of pilocarpine (ED(50) = 0.05 microg/animal), picrotoxin (ED(50) = 0.02 microg/animal), kainic acid (ED(50) = 0.2 microg/animal) and the systemic administration of PTZ (ED(50) = 0.03 microg/animal). "
2.	Cognitive Dysfunction 01/16/2007 - "Finally, when tested for cognitive impairments in the Morris water maze, the i.c.v. injection of FrPbAII did not alter escape latencies of treated animals. "
3.	Glaucoma 06/01/2006 - "According to our experimental glaucoma data in rat retina, FrPbAII is able to cross the blood-retina barrier and promote effective protection of retinal layers submitted to ischemic conditions. "

Related Drugs and Biologics

1.	Pilocarpine (Ocusert)
2.	Picrotoxin
3.	Kainic Acid (Kainate)
4.	Retinaldehyde (Retinal)
5.	Bicuculline
6.	Anticonvulsants (Antiepileptic Drugs)
7.	nipecotic acid