spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- one

structure in first source

Also Known As:

ST 101; ST-101; ST101 cpd; ZSET 1446; ZSET1446

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one: 7
    - Spiro Compounds: 2
      - spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one: 7
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one: 7
- Spiro Compounds: 2
  - spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one: 7

Experts

1.	Yamaguchi, Yoshimasa: 5 articles (02/2016 - 06/2006)
2.	Hino, Masataka: 4 articles (02/2016 - 07/2008)
3.	Takeda, Kentaro: 3 articles (02/2016 - 01/2012)
4.	Matsuno, Toshiyuki: 2 articles (01/2012 - 06/2006)
5.	Saito, Kenichi: 2 articles (01/2012 - 06/2006)
6.	Fukunaga, Kohji: 2 articles (04/2011 - 07/2008)
7.	Han, Feng: 2 articles (04/2011 - 07/2008)
8.	Moriguchi, Shigeki: 2 articles (04/2011 - 07/2008)
9.	Shioda, Norifumi: 2 articles (04/2011 - 07/2008)
10.	Yamamoto, Yui: 2 articles (04/2011 - 07/2008)

Related Diseases

1.	Memory Disorders (Memory Loss) 07/01/2008 - "Here, we found that chronic oral administration of spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) (0.1-1 mg/kg/day), a novel cognitive enhancer, significantly improved memory deficits as assessed by Y-maze and novel object recognition tasks in OBX mice. "
2.	Alzheimer Disease (Alzheimer's Disease) 06/01/2006 - "These results suggest that ZSET1446 may be a potential candidate for development as a therapeutic agent to manage cognitive impairment associated with conditions such as Alzheimer's disease." 02/01/2007 - "ZSET1446 would be a potential candidate for further preclinical study aimed at the treatment of cognitive deficits in Alzheimer's disease and schizophrenia, as well as METH psychosis." 02/01/2016 - "ZSET1446 (ST101; spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) is a newly synthesized azaindolizinone derivative that significantly improves learning deficits in various types of Alzheimer disease (AD) models in rats. "
3.	Schizophrenia (Dementia Praecox) 02/01/2007 - "ZSET1446 would be a potential candidate for further preclinical study aimed at the treatment of cognitive deficits in Alzheimer's disease and schizophrenia, as well as METH psychosis."
4.	Psychotic Disorders (Schizoaffective Disorder) 02/01/2007 - "ZSET1446 would be a potential candidate for further preclinical study aimed at the treatment of cognitive deficits in Alzheimer's disease and schizophrenia, as well as METH psychosis."
5.	Cognitive Dysfunction 06/01/2006 - "These results suggest that ZSET1446 may be a potential candidate for development as a therapeutic agent to manage cognitive impairment associated with conditions such as Alzheimer's disease." 01/01/2013 - "In the novel object recognition task, ZSET1446 (also coded as ST101) enhanced object recognition memory in mice and ameliorated cognitive impairment caused by scopolamine in rats. " 04/01/2011 - "These results suggest that ZSET1446 action via stimulation of the cholinergic system elicits improvement of the depression and cognitive impairment observed in Alz disease patients." 01/01/2012 - "Effects of the azaindolizinone derivative ZSET1446/ST101, a newly synthesized cognitive enhancer, on cognitive impairment and deposition of amyloid β (Aβ) were assessed in the SAMP8. " 02/01/2007 - "The effect of ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) on cognitive impairment in mice, previously treated with methamphetamine (METH) at a dose of 1 mg/kg for 7 days, was investigated. "

Related Drugs and Biologics

1.	indan
2.	pyridine
3.	Nootropic Agents (Nootropics)
4.	Cholinergic Agents (Cholinergics)
5.	Amyloid beta-Peptides
6.	Scopolamine (Hyoscine)
7.	Methamphetamine (Desoxyn)

Related Therapies and Procedures

1.	Oral Administration