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dibenzocyclooctadiene lignan

structure in first source

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        dibenzocyclooctadiene lignan: 9
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclooctanes: 4
        dibenzocyclooctadiene lignan: 9

Experts

1.	Hu, Xun: 2 articles (07/2013 - 01/2012)
2.	Liu, Zhen: 2 articles (07/2013 - 01/2012)
3.	Zhang, Biao: 2 articles (07/2013 - 01/2012)
4.	Cha, Kwang Hyun: 1 article (08/2022)
5.	Cho, Su-Yeon: 1 article (08/2022)
6.	Choi, Ki Young: 1 article (08/2022)
7.	Ha, Ngoc Minh: 1 article (08/2022)
8.	Kang, Kyungsu: 1 article (08/2022)
9.	Kim, Jeong-Ho: 1 article (08/2022)
10.	Kim, Joo Yeon: 1 article (08/2022)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2015 - "Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignan isolated from the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill, possesses various biological activities, such as hepatic protection, anti-tumor, anti-inflammatory and anti-cardiovascular properties. " 01/01/2012 - "Gomisin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra chinensis, has been reported as an anti-cancer substance. " 01/01/2012 - "In the preliminary studies, we found that schisandrin B (Sch B), a naturally-occurring dibenzocyclooctadiene lignan with very low toxicity, could suppress cancer metastasis. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2012 - "In the preliminary studies, we found that schisandrin B (Sch B), a naturally-occurring dibenzocyclooctadiene lignan with very low toxicity, could suppress cancer metastasis. " 07/15/2013 - "Here we show (1) that TGF-β induces ROS production in breast cancer 4T1 cells and enhances cell migration and that the effect of TGF-β depends on NOX4 expression, (2) that knockdown of NOX4 via RNAi significantly decreases the migration ability of 4T1 cells in the presence or absence of TGF-β and significantly attenuates distant metastasis of 4T1 cells to lung and bone, (3) that Schisandrin B (Sch B), a naturally occurring dibenzocyclooctadiene lignan with very low toxicity, is a novel NOX inhibitor and its IC50 toward NOX4 is 9.3μM, and (4) that Sch B suppresses TGF-β-induced and NOX4-associated ROS production in 4T1 cells and inhibits TGF-β-enhanced cell migration. "
3.	Inflammation (Inflammations) 08/01/2022 - "We evaluated the effects of schisandrin C, a dibenzocyclooctadiene lignan from Schisandra chinensis, on intestinal inflammation and permeability dysfunction in gut mimetic systems: cultured intestinal cells, intestinal organoids, and a Caenorhabditis elegans model. " 10/01/2016 - "The objective of this study is to investigate the effect of gomisin N, a dibenzocyclooctadiene lignan isolated from the dried fruits of Schisandra chinensis (Turcz.) Baill., which exhibited inhibitory effects of the bacterial endotoxin lipopolysaccharide (LPS)-induced NO production in a screening assay, on inflammation-induced depressive symptoms. "
4.	Breast Neoplasms (Breast Cancer) 02/01/2010 - "Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells." 07/15/2013 - "Here we show (1) that TGF-β induces ROS production in breast cancer 4T1 cells and enhances cell migration and that the effect of TGF-β depends on NOX4 expression, (2) that knockdown of NOX4 via RNAi significantly decreases the migration ability of 4T1 cells in the presence or absence of TGF-β and significantly attenuates distant metastasis of 4T1 cells to lung and bone, (3) that Schisandrin B (Sch B), a naturally occurring dibenzocyclooctadiene lignan with very low toxicity, is a novel NOX inhibitor and its IC50 toward NOX4 is 9.3μM, and (4) that Sch B suppresses TGF-β-induced and NOX4-associated ROS production in 4T1 cells and inhibits TGF-β-enhanced cell migration. "
5.	Sepsis (Septicemia) 04/15/2014 - "A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis."

Related Drugs and Biologics

1.	schizandrin B
2.	Lipopolysaccharides
3.	Endotoxins
4.	schizandrin A
5.	schizandrol B
6.	schizandrin C