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3- (6- methylpyridin- 2- ylethynyl)cyclohex- 2- enone- O- methyloxime

an mGluR5 antagonist; stsructure in first source

Also Known As:

3-(6-methylpyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime; ABP 688; ABP-688; ABP688

Networked: 20 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Oximes: 1292
      - 3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime: 20
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime: 20

Experts

1.	Rosa-Neto, Pedro: 4 articles (01/2021 - 04/2016)
2.	Soucy, Jean-Paul: 4 articles (01/2021 - 04/2016)
3.	DuBois, Jonathan M: 3 articles (01/2021 - 10/2016)
4.	Guiot, Marie-Christine: 3 articles (01/2021 - 10/2016)
5.	Hall, Jeffery A: 3 articles (01/2021 - 10/2016)
6.	Kobayashi, Eliane: 3 articles (01/2021 - 10/2016)
7.	Rousset, Olivier G: 3 articles (01/2021 - 10/2016)
8.	Di Paolo, Thérèse: 3 articles (10/2013 - 07/2011)
9.	Gasparini, Fabrizio: 3 articles (10/2013 - 07/2011)
10.	Gomez-Mancilla, Baltazar: 3 articles (10/2013 - 07/2011)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2020 - "In this study, we investigated their significance (using [11 C]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. " 02/09/2023 - "For positron emission tomography (PET) ligands, such as [11C]ABP688, to be able to provide more evidence about the glutamatergic hypothesis in schizophrenia (SZ), quantification bias during dynamic PET studies and its propagation into the estimated values of non-displaceable binding potential (BPND) must be addressed. "
2.	Tauopathies 01/01/2020 - "Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[11C]ABP688 and [11C]flumazenil, respectively. "
3.	Cocaine-Related Disorders (Cocaine Addiction) 01/15/2014 - "The results of the study showed that cocaine addiction was associated with a 20% to 22% reduction in [(11)C]ABP688 binding in the striatum. " 01/15/2014 - "Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy."
4.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 10/15/2020 - "Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study." 10/15/2020 - "We aimed to evaluate [3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-0-11C-methyloxime] ([11C]ABP688) small animal positron emission tomography (μPET) as a biomarker to visualize possible longitudinal changes in metabotropic glutamate receptor 5 (mGluR5) availability in the brain of SAP90/PSD-95 associated protein 3 (Sapap3) knockout (ko) mice, showing obsessive compulsive disorder (OCD)-like behavior. "
5.	Temporal Lobe Epilepsy 01/01/2021 - "Previous positron emission tomography (PET) studies using [11 C]ABP688 show reduced metabotropic glutamate receptor type 5 (mGluR5) allosteric binding site availability in the epileptogenic hippocampus of mesial temporal lobe epilepsy (MTLE) patients. "

Related Drugs and Biologics

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	Ligands
3.	Pilocarpine (Ocusert)
4.	Flumazenil (Romazicon)
5.	Metabotropic Glutamate 5 Receptor
6.	Glutamic Acid (Glutamate)
7.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
8.	Levodopa (L Dopa)
9.	Glutamate Receptors (Glutamate Receptor)
10.	Biomarkers (Surrogate Marker)