shigyaku-san (Si-Ni-San)

traditional Kampo medicine composed of Bupleuri radix, Glycyrrhizae radix, Paeonia radix, Aurantii fructus; used for treatment of gastritis and gastric ulcers

Also Known As:

Si-Ni-San; Shigyakusan; TJ-35; sinisan

Networked: 43 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Extracts: 3916
      - Chinese Herbal Drugs: 73
        shigyaku-san: 43
Pharmaceutical Preparations
- Chinese Herbal Drugs: 73
  - shigyaku-san: 43

Experts

1.	Chen, Ting: 6 articles (01/2019 - 06/2003)
2.	Xu, Qiang: 6 articles (11/2009 - 06/2003)
3.	Sun, Yang: 5 articles (11/2009 - 06/2003)
4.	Li, Bangjie: 2 articles (06/2021 - 10/2019)
5.	Yang, Xinghao: 2 articles (06/2021 - 10/2019)
6.	Cheng, Fafeng: 2 articles (01/2021 - 04/2017)
7.	Ma, Chongyang: 2 articles (01/2021 - 04/2017)
8.	Wang, Qingguo: 2 articles (01/2021 - 04/2017)
9.	Wang, Xueqian: 2 articles (01/2021 - 04/2017)
10.	Wang, Zisong: 2 articles (01/2021 - 04/2017)

Related Diseases

1.	Colitis 04/06/2023 - "Si-Ni-San (SNS) has been considered to effectively treat colitis in clinical practice during thousands of years, yet whether SNS ameliorated acute colitis mouse model by modulating intestinal flora has not been distinctly elucidated. " 04/06/2023 - "Si-Ni-San improves experimental colitis by favoring Akkermensia colonization." 04/01/2021 - "Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation." 11/01/2009 - "Si-Ni-San and glycyrrhizin significantly ameliorated TNBS-induced colitis with reduced mortality and recovery of body weights. " 11/01/2009 - "Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance."
2.	Inflammation (Inflammations) 01/01/2019 - "Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity." 04/01/2021 - "Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation." 11/01/2009 - "In addition, Si-Ni-San and glycyrrhizin dose-dependently decreased macroscopic inflammation scores, microscopic histological scores, and myeloperoxidase activity. "
3.	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 07/01/2011 - "Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. " 01/01/2020 - "The traditional Chinese prescription Si-Ni-San, of which paeoniflorin is a constituent, is often used in treating depression and functional gastrointestinal disorders. " 08/02/2016 - "Qizhiweitong particles (QZWT) which is derived from the Sinisan decoction in Shang Han Za Bing Lun, composed of Bupleurum chinenis, Paeonia obovata, Citrus aurantium L., Glycyrrhiza uralensis Fisch., Cyperus rotundus and Rhizoma Corydalis is a traditional Chinese medicine (TCM) treating gastrointestinal diseases. "
4.	Interstitial Cystitis (Interstitial Cystitis, Chronic) 07/01/2023 - "Si-Ni-San Ameliorates the Clinical Symptoms of Interstitial Cystitis/Bladder Pain Syndrome in Rats by Decreasing the Expression of Inflammatory Factors." 07/01/2023 - "To observe the therapeutic effect of Si-Ni-San (SNS) on interstitial cystitis/bladder pain syndrome (IC/BPS) in rats, and explore the possible regulatory mechanism of SNS on IC/BPS combined with transcriptome analysis. "
5.	Obesity 02/10/2023 - "Si-Ni-SAN ameliorates obesity through AKT/AMPK/HSL pathway-mediated lipolysis: Network pharmacology and experimental validation."

Related Drugs and Biologics

1.	Interferon Type I
2.	Glycyrrhizic Acid (Glycyrrhizin)
3.	Sulfonic Acids
4.	naringenin
5.	Powders
6.	liquiritigenin
7.	hesperetin
8.	Picryl Chloride (Trinitrochlorobenzene)
9.	peoniflorin
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Oral Administration
3.	Kampo Medicine (Kampo)
4.	Therapeutics
5.	Traditional Medicine (Folk Remedies)