brefelamide

06/01/2016 - "In this study, we investigated the mechanisms by which brefelamide inhibited 1321N1 and PC12 rat pheochromocytoma cell proliferation. "

04/01/2020 - "Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy."
04/01/2020 - "In the present study, two amide analogues of brefelamide, TPFS-201 and TPFS-202, were identified as small molecular immune checkpoint inhibitors, as they downregulated PD-L1 expression in tumor cells. "

01/01/2017 - "This study investigated the inhibitory effects of brefelamide and its methyl ether derivative on DENV-3 by measuring changes in OPN levels in human THP-1 and 293T cell lines infected at different multiplicities of infection and post-infection time points. "
01/01/2017 - "Induction of Osteopontin by Dengue Virus-3 Infection in THP-1 Cells: Inhibition of the Synthesis by Brefelamide and Its Derivative."
01/01/2017 - "These results suggest that brefelamide and its methyl ether derivative have therapeutic effects in preventing inflammation, coagulopathy, and fibrinolysis caused by OPN upregulation induced by DENV-3 infection."

06/01/2016 - "Effect of brefelamide on HGF-induced survival of 1321N1 human astrocytoma cells."
08/15/2009 - "We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human astrocytoma cells. "
09/01/2007 - "In addition, brefelamide inhibited the cellular proliferation of 1321N1 human astrocytoma cells. "
10/28/2005 - "Isolation and synthesis of a new aromatic compound, brefelamide, from dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells."
01/02/2018 - "Effect of brefelamide on proliferation of 1321N1 human astrocytoma cells induced by glial cell line-derived neurotrophic factor."

10/01/2016 - "Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells."