NNC 38-1049

selective histamine H3 receptor antagonist; structure in first source

Also Known As:

1-cyclopentyl-4-(4-(4-chlorophenyl)-4-oxobutanoyl)piperazine; NNC 0038-0000-1049

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Body Weight (Weight, Body) 12/01/2005 - "Twice daily administration of 20 mg/kg of NNC 38-1049 in old and dietary obese rats resulted in sustained reduction of food intake throughout a 2-week study, and was associated with a highly significant (P<0.01) decrease in body weight compared with controls (-18.4+/-3.4 vs +0.4+/-2.7 g). "
2.	Pica (Geophagia) 12/01/2005 - "Plasma and brain levels of NNC 38-1049 and acute effects on food intake and energy expenditure were followed after oral doses of 3-60 mg/kg. Potential side effects were examined with rat models of behaviour satiety sequence (BSS), pica behaviour and conditioned taste aversion (CTA). "