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pedalitin

has antioxidant activity; isolated from Rabdosia japonica; structure in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        pedalitin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        pedalitin: 4

Experts

1.	Andrade, Carolina Horta: 1 article (01/2021)
2.	Coimbra, Lais Durco: 1 article (01/2021)
3.	Ekins, Sean: 1 article (01/2021)
4.	Guido, Rafael V C: 1 article (01/2021)
5.	Lima, Caroline Sprengel: 1 article (01/2021)
6.	Marques, Rafael Elias: 1 article (01/2021)
7.	Mesquita, Nathalya Cristina de Moraes Roso: 1 article (01/2021)
8.	Mottin, Melina: 1 article (01/2021)
9.	Oliva, Glaucius: 1 article (01/2021)
10.	Proença-Modena, José Luiz: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2021 - "The results presented here demonstrate the potential of pedalitin as a candidate for hit-to-lead (H2L) optimization studies towards the discovery of antiviral drug candidates to treat ZIKV infections."
2.	Melanoma (Melanoma, Malignant) 07/01/2008 - "Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC(50) of 30 microm (9.5 microg/mL). "
3.	Kidney Calculi (Kidney Stone) 03/01/2020 - "and its active compound pedalitin on urease expression - For the management of kidney stone."
4.	Zika Virus Infection 11/30/2022 - "Moreover, pedalitin also displayed antiviral activity on ZIKV infection with an EC50 of 19.28 µM cell-based assays, with low toxicity in Vero cells (CC50 = 83.66 µM) and selectivity index of 4.34. "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Urease