R-138727

an active metabolite of CS-747 (prasugrel, LY640315) and P2Y12 receptor inhibitor; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Jakubowski, Joseph A: 2 articles (10/2016 - 05/2013)
2.	Sugidachi, Atsuhiro: 2 articles (10/2016 - 05/2013)
3.	Iwanaga, Kazunori: 1 article (01/2021)
4.	Nomura, Yukihiro: 1 article (01/2021)
5.	Takubo, Hiroaki: 1 article (01/2021)
6.	Taniguchi, Toshio: 1 article (01/2021)
7.	Mizuno, Makoto: 1 article (10/2016)
8.	Ohno, Kousaku: 1 article (10/2016)
9.	Tomizawa, Atsuyuki: 1 article (10/2016)
10.	Barnard, Marc R: 1 article (05/2013)

1.	Chronic Renal Insufficiency 01/01/2021 - "We investigated the predictability of changes in the exposure to captopril, tiopronin, the active form of dalcetrapib and the active metabolite of prasugrel, R-138727, all of which have a sulfhydryl group, in moderate and severe chronic kidney disease (CKD) patients using a constructed PBPK model. "
2.	Intracranial Thrombosis (Cerebral Thrombosis) 10/05/2016 - "R-138727 was administered 1h after MCAO induction, and its effects on thrombosis, cerebral infarction, and neurological deficits were determined (n=8-10). "
3.	Thrombosis (Thrombus) 05/15/2013 - "The complementary effects of abciximab and R-138727 on platelet activation, aggregation, and procoagulant activity suggest their combined use may, to a greater degree than with either agent alone, reduce thrombus formation in vivo."
4.	Neurologic Manifestations (Neurological Manifestations) 10/05/2016 - "The active metabolite of prasugrel, R-138727, improves cerebral blood flow and reduces cerebral infarction and neurologic deficits in a non-human primate model of acute ischaemic stroke."
5.	Infarction (Infarctions) 10/05/2016 - "R-138727 significantly reduced total ischaemic infarction volumes (P=0.0147), including those of basal ganglia (P=0.0028), white matter (P=0.0393), and haemorrhagic infarction (P=0.0235). " 10/05/2016 - "R-138727 was administered 1h after MCAO induction, and its effects on thrombosis, cerebral infarction, and neurological deficits were determined (n=8-10). "