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dihydromotuporamine C

has antineoplastic activity; structure in first source

Also Known As:

dhMotC

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - dihydromotuporamine C: 5
Organic Chemicals: 133
- Amines: 4871
  - Propylamines: 1
    - dihydromotuporamine C: 5

Experts

1.	Roberge, Michel: 3 articles (01/2009 - 02/2004)
2.	Phanstiel, Otto: 2 articles (10/2017 - 05/2014)
3.	McHardy, Lianne M: 2 articles (01/2009 - 02/2004)
4.	Rebérioux, Delphine: 2 articles (01/2009 - 03/2004)
5.	Roskelley, Calvin D: 2 articles (01/2009 - 02/2004)
6.	Andersen, Raymond J: 2 articles (03/2004 - 02/2004)
7.	Chaplin, Kelvin J: 1 article (10/2017)
8.	Skruber, Kristen: 1 article (10/2017)
9.	Altomare, Deborah A: 1 article (05/2014)
10.	Baker, Cheryl: 1 article (05/2014)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 05/22/2014 - "Mice injected with metastatic human L3.6pl pancreatic cancer cells demonstrated significant reduction in liver metastases when treated with N(1)-(3-aminopropyl)-N(3)-(cyclopentadecylmethyl)propane-1,3-diamine compared with dihydromotuporamine C. " 10/26/2017 - "Dihydromotuporamine C contains a large macrocycle and an appended polyamine component and was shown to be both antimetastatic and cytotoxic to human L3.6pl pancreatic cancer cells. "
2.	Neoplasm Metastasis (Metastasis) 05/22/2014 - "Mice injected with metastatic human L3.6pl pancreatic cancer cells demonstrated significant reduction in liver metastases when treated with N(1)-(3-aminopropyl)-N(3)-(cyclopentadecylmethyl)propane-1,3-diamine compared with dihydromotuporamine C. " 03/30/2004 - "We demonstrate that dihydromotuporamine C, a compound in preclinical development that inhibits angiogenesis and metastasis by an unknown mechanism, targets sphingolipid metabolism. "
3.	Neoplasms (Cancer) 02/15/2004 - "Experiments with serum-starved Swiss 3T3 fibroblasts showed that micromolar concentrations of dhMotC that inhibit tumor cell invasion induce the formation of new stress fibers and large focal adhesion complexes that are dispersed around the entire cell periphery. " 01/14/2009 - "Using the example of the tumor cell invasion inhibitor dihydromotuporamine C, we show that a more complete picture of drug action can be obtained by combining different chemical genomics approaches--analysis of the sensitivity of rho0 cells lacking mitochondrial DNA, drug-induced haploinsufficiency, suppression of drug sensitivity by gene overexpression and chemical-genetic synthetic lethality screening using strains deleted of nonessential genes. " 02/15/2004 - "The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange."
4.	Breast Neoplasms (Breast Cancer) 02/15/2004 - "C3 exoenzyme loading also reestablishes elongated MDA231 breast tumor cell invasion in the presence of dhMotC. " 02/15/2004 - "Here, we show that dhMotC causes subtle cytoskeletal alterations in highly invasive MDA231 breast tumor cells that include an increase in the thickness and number of cytoplasmic actin stress fibers. "

Related Drugs and Biologics

1.	Sphingolipids
2.	Sodium
3.	Protons (Proton)
4.	Polyamines
5.	Mitochondrial DNA (mtDNA)