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hippuristanol

from the gorgonian Isis hippuris

Also Known As:

22-epi-hippuristanol

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        hippuristanol: 6
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - hippuristanol: 6

Experts

1.	Ishikawa, Chie: 2 articles (09/2013 - 03/2011)
2.	Mori, Naoki: 2 articles (09/2013 - 03/2011)
3.	Senba, Masachika: 2 articles (09/2013 - 03/2011)
4.	Tanaka, Junichi: 2 articles (09/2013 - 03/2011)
5.	Désaubry, Laurent: 1 article (01/2017)
6.	Malka-Mahieu, Hélène: 1 article (01/2017)
7.	Newman, Michelle: 1 article (01/2017)
8.	Robert, Caroline: 1 article (01/2017)
9.	Vagner, Stéphan: 1 article (01/2017)
10.	Katano, Harutaka: 1 article (09/2013)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2010 - "To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. " 05/15/2010 - "Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. " 03/15/2011 - "In addition to its in vitro effects, hippuristanol suppressed tumor growth in mice with severe combined immunodeficiency harboring tumors induced by inoculation of HTLV-1-infected T cells. " 12/01/2009 - "Several inhibitors have been characterized over the last 5 years that target the ribosome recruitment phase (eukaryotic initiation factor [eIF]4E [antisense oligonucleotides and 4EGI-1] or eIF4A [pateamine A, hippuristanol and silvestrol]), some of which demonstrate activity in preclinical cancer models. "
2.	Carcinogenesis 01/01/2017 - "Here, we review the contribution of the eIF4F complex to tumorigenesis, with a focus on its role in chemoresistance as well as the promising use of new small-molecule inhibitors of the complex, including flavaglines/rocaglates, hippuristanol, and pateamine A. "
3.	Primary Effusion Lymphoma 09/06/2013 - "Hippuristanol reduces the viability of primary effusion lymphoma cells both in vitro and in vivo."
4.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 03/15/2011 - "In addition to its in vitro effects, hippuristanol suppressed tumor growth in mice with severe combined immunodeficiency harboring tumors induced by inoculation of HTLV-1-infected T cells. "
5.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/15/2011 - "We evaluated the anti-adult T-cell leukemia (ATL) effects of hippuristanol, an eukaryotic translation initiation inhibitor from the coral Isis hippuris. " 03/15/2011 - "Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia."

Related Drugs and Biologics

1.	Eukaryotic Initiation Factor-4F (EIF4F)
2.	pateamine A
3.	Eukaryotic Initiation Factor-4E
4.	RNA Helicases (RNA Helicase)
5.	Sirolimus (Rapamycin)
6.	Antisense Oligonucleotides
7.	Peptide Initiation Factors (Initiation Factor)
8.	DNA (Deoxyribonucleic Acid)
9.	silvestrol