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GQ-ODN T40214

Subscribe to New Research on GQ-ODN T40214

a G-quartet oligonucleotide with antineoplastic activity; base sequence in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 2866
  - Polynucleotides: 78
    - Oligonucleotides: 1310
      - Oligodeoxyribonucleotides: 1091
        GQ-ODN T40214: 3

Experts

1.	Jing, Naijie: 3 articles (07/2007 - 09/2004)
2.	Mao, Li: 2 articles (07/2007 - 02/2006)
3.	Zhu, Qiqing: 2 articles (07/2007 - 02/2006)
4.	Yuan, Ping: 2 articles (07/2007 - 02/2006)
5.	Tweardy, David J: 2 articles (02/2006 - 09/2004)
6.	Li, Yidong: 2 articles (02/2006 - 09/2004)
7.	Feng, Lili: 1 article (07/2007)
8.	Garcia, Gabriela E: 1 article (07/2007)
9.	Weerasinghe, Priya: 1 article (07/2007)
10.	Jing, Ling: 1 article (09/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2006 - "We employed five regimens in the treatment of nude mice with tumors of head and neck squamous cell carcinoma (HNSCC): placebo, paclitaxel, GQ-ODN T40214, GQ-ODN T40231, and T40214 plus paclitaxel. " 07/01/2007 - "Results show that GQ-ODN T40214 and T40231 significantly suppress the growth of NSCLC tumors in nude mice by selectively inhibiting the activation of Stat3 and its downstream proteins Bcl-2, Bcl-xL, Mcl-1, survivin, VEGF, Cyclin D1 and c-myc; thereby, promoting apoptosis and reducing angiogenesis and cell proliferation. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/01/2006 - "We employed five regimens in the treatment of nude mice with tumors of head and neck squamous cell carcinoma (HNSCC): placebo, paclitaxel, GQ-ODN T40214, GQ-ODN T40231, and T40214 plus paclitaxel. "
3.	Breast Neoplasms (Breast Cancer) 09/15/2004 - "To establish the effectiveness of GQ-ODN as a potential new chemotherapeutic agent, we systemically administered GQ-ODN (T40214 or T40231) plus polyethyleneimine or polyethyleneimine alone (placebo) by tail-vein injection into nude mice with prostate and breast tumor xenografts. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Cyclin D1
3.	Paclitaxel (Taxol)
4.	Proteins (Proteins, Gene)
5.	Polyethyleneimine
6.	GQ-ODN T40231

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)