irigenin

01/01/2023 - "In summary, irigenin ameliorates LPS-induced ALI by suppressing pulmonary inflammation and apoptosis via inactivation of the MAPK signaling pathway. "

05/01/2020 - "This study was aimed to explore the effects of irigenin (IR), as an isoflavonoid isolated from the rhizome of Belamcanda chinensis, on DOX-induced cardiotoxicity using the in vivo and in vitrostudies. "
05/01/2020 - "Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425."

05/01/2005 - "The aim of this study was to identify genomic aberrations in endometrial cancer cells treated with the phyto-estrogenic compounds tectorigenin, irigenin and apigenin and to compare with those treated with beta-estradiol using array-based comparative genomic hybridisation (array CGH). "

12/01/2004 - "These in vitro studies demonstrate a role for tectorigenin and irigenin in regulating prostate cancer cell number by inhibiting proliferation through cell cycle regulation."

01/01/2022 - "Finally, we found that irigenin inhibited the growth of tumor in GBM xenograft mice model through inactivation of YAP. "
01/01/2022 - "Furthermore, overexpression of YAP partially restored the anti-tumor effects of irigenin on GBM cells in vitro. "
12/01/2018 - "Irigenin (Iri), isoflavonoids, can be isolated from the rhizome of Belamcanda chinensis, and has been shown anti-cancer properties. "
01/01/2020 - "Inhibitory effects of irigenin on tumor growth and metastasis suggest the potential of this agent as an anticancer therapeutic."
01/01/2020 - "In orthotopic breast cancer mouse models, irigenin injection remarkably reduced tumor growth and lung metastases. "