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1- (2- amino- 2- carboxyethyl)- 3- (2- carboxybenzyl)pyrimidine- 2,4- dione

a GluR5 receptor antagonist; structure in first source

Also Known As:

UBP 302; UBP-302; UBP302

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - 1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        Thymine: 735
        1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione: 3

Experts

1.	Acon-Chen, Cindy: 1 article (06/2016)
2.	Koenig, Jeffrey A: 1 article (06/2016)
3.	Shih, Tsung-Ming: 1 article (06/2016)
4.	Smith, Garrett R: 1 article (06/2016)
5.	Thomas, Thaddeus P: 1 article (06/2016)
6.	Truitt, Amber R: 1 article (06/2016)
7.	Apland, James P: 1 article (11/2014)
8.	Aroniadou-Anderjaska, Vassiliki: 1 article (11/2014)
9.	Braga, Maria F M: 1 article (11/2014)
10.	Figueiredo, Taiza H: 1 article (11/2014)

Related Diseases

1.	Seizures (Absence Seizure) 11/01/2014 - "The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302." 11/01/2014 - "Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats. " 06/01/2016 - "Several drugs (topiramate, clobazam, pregnanolone, allopregnanolone, UBP 302, cyclopentyladenosine [CPA], ketamine, midazolam and scopolamine) have been identified as potential neuroprotectants that may terminate seizures and reduce brain damage. "
2.	Pruritus (Itching) 10/15/2023 - "On the other hand, UBP310 or UBP302 and the siRNAs of KA receptor subunits 1-3 significantly inhibited the induction of scratching events in mice treated with histamine, while no significant change was observed in the induction of spontaneous scratching events in mice with chronic pruritus. " 10/15/2023 - "Therefore, the roles of KA receptors in histamine-dependent and -independent itch were investigated using CNQX, an AMPA/KA receptors antagonist, UBP310 and UBP302, antagonists of KA receptors, and small interfering (si)RNAs against KA receptor subunits in mice with acute and chronic pruritus. "

Related Drugs and Biologics

1.	Kainic Acid Receptors (Kainate Receptor)
2.	Soman
3.	willardiine
4.	6-Cyano-7-nitroquinoxaline-2,3-dione (6 Cyano 7 nitroquinoxaline 2,3 dione)
5.	Neuroprotective Agents
6.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
7.	Scopolamine (Hyoscine)
8.	Pregnanolone (Allopregnanolone)
9.	Midazolam (Versed)
10.	Ketamine