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SA5845

Also Known As:

1-(3,4-dimethoxyphenethyl)-4-(3-(4-fluorophenyl)propyl)piperazine

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - SA5845: 1

Experts

1.	Elsinga, Philip H: 1 article (12/2005)
2.	Ishiwata, Kiichi: 1 article (12/2005)
3.	Kawamura, Kazunori: 1 article (12/2005)
4.	Kobayashi, Tadayuki: 1 article (12/2005)
5.	Kubota, Kazuo: 1 article (12/2005)
6.	Maeda, Minoru: 1 article (12/2005)
7.	Ono, Mayumi: 1 article (12/2005)

Related Diseases

1.	Carcinoma (Carcinomatosis) 12/01/2005 - "On the other hand, in the PET studies of rabbits, the uptake of [11C]SA5845 in the VX-2 carcinoma was relatively higher than that of [11C]SA4503, because of a much higher density of sigma2 receptors compared to sigma1 receptors in the VX-2 tissue, and the uptake of both tracers in the VX-2 tissue was decreased by carrier-loading and pre-treatment with haloperidol ([11C]SA5845, 53% and 26%, respectively; [11C]SA4503, 41% and 22%, respectively at 30 minutes after injection). "
2.	Neoplasms (Cancer) 12/01/2005 - "Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET." 12/01/2005 - "Therefore, [11C]SA5845 and [11C]SA4503 may be potential ligands for PET imaging of sigma receptor-rich tumors."
3.	Hepatocellular Carcinoma (Hepatoma) 12/01/2005 - "In a cell growth assay in vitro, neither SA5845 nor SA4503 (<10 microM) showed any inhibitory effect on proliferation of the AH109A hepatoma cells. "

Related Drugs and Biologics

1.	Haloperidol (Haldol)
2.	SA 4503
3.	sigma Receptors (sigma Receptor)
4.	Ligands