flubendiamide

activates ryanodine-sensitive calcium release channels in insects; structure in first source

Also Known As:

3-Iodo-N2-(2-methyl-1-(methylsulfonyl)propan-2-yl)-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)phthalamide; 3-iodo-N-(2-methanesulfonyl-1,1-dmethylethyl)-N'-(2-methyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)phenyl)phthalamide

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Food Safety Commission of Japan: 1 article (03/2019)
2.	Pessah, Isaac N: 1 article (01/2019)
3.	Truong, Kim M: 1 article (01/2019)
4.	Akbar, Shaik Mohammad: 1 article (09/2017)
5.	Jayalakshmi, Senigala K: 1 article (09/2017)
6.	Nareshkumar, Bharat: 1 article (09/2017)
7.	Sharma, Hari Chand: 1 article (09/2017)
8.	Sreeramulu, Kuruba: 1 article (09/2017)
9.	Dumka, Vinod Kumar: 1 article (01/2015)
10.	Venkatachalam, Dinakaran: 1 article (01/2015)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2015 - "In flubendiamide-exposed animals an intravenous dose of 2mg/kg body weight would maintain the therapeutic plasma levels required to be effective against the bacterial pathogens with MIC values ≤0.39μg/mL for only 12h, whereas in untreated buffalo calves the same dose of 2mg/kg body weight would maintain the plasma levels up to 24h, The study revealed that subchronic flubendiamide exposure significantly alters the disposition of cefquinome in buffalo calves. "
2.	Hypertrophy 03/01/2019 - "Major adverse effects of flubendiamide include hepatocellular hypertrophy, fatty changes in hepatocytes, follicular epithelial cell hypertrophy in thyroid and ocular enlarged eye in rats. " 03/01/2019 - "Adverse effects elicited by a single oral administration of flubendiamide would be abnormalities in eyes such as ocular hypertrophy and iris adhesion in offspring, which were obtained in a two-generation reproductive toxicity study, a one-generation reproductive toxicity study and a neurodevelopmental toxicity study in rats. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 09/01/2017 - "Evaluation of flubendiamide-induced mitochondrial dysfunction and metabolic changes in Helicoverpa armigera (Hubner)."
4.	Paralysis (Palsy) 06/01/2023 - "Flubendiamide is a phthalic acid diamide insecticide that ceases the function of insect muscle leading to paralysis and death. "
5.	Malignant Hyperthermia 01/01/2019 - "Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance."

Related Drugs and Biologics

1.	cefquinome
2.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
3.	Insecticides
4.	Diamide
5.	chlorantranilipole
6.	phthalic acid (phthalate)

Related Therapies and Procedures

1.	Oral Administration