Colivelin

01/01/2016 - "Protective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model."
07/01/2008 - "Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease."
06/01/2010 - "[Colivelin--drug therapy for patients with Alzheimer's disease]."
07/01/2008 - "Humanin (HN) and its derivatives, such as Colivelin (CLN), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. "
02/01/2015 - "Colivelin (CL), first reported in 2005, is the most potent member of the humanin family of neuroprotective peptides with in vitro and in vivo rescuing action against insults associated with Alzheimer's disease (AD). "

01/01/2022 - "In conclusion, our data support that damage of the glycocalyx is an early pathogenetic event during sepsis and that colivelin may have therapeutic potential for the treatment of sepsis-associated endothelial dysfunction."
01/01/2022 - "Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice."
01/01/2022 - "In the current study, we aimed to determine the potential therapeutic effects of colivelin in endothelial dysfunction and outcomes of sepsis in vivo. "
01/01/2022 - "Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP. "

01/01/2019 - "In conclusion, Colivelin induce anti-apoptotic genes up-regulation, and activate JAK/STAT3 signaling after ischemic stroke, which may contribute to its effects of rescuing ischemic neuronal death and axonal remodeling. "
01/01/2019 - "This study may justify further works to examine Colivelin as a single or adjunct therapy in ischemic stroke."

03/01/2023 - "STAT3 activator Colivelin reversed the effects of DOCK8 knockdown on IBA-1 expression, inflammation, migration, invasion and M1 cell polarization. "
01/01/2018 - "In vitro, we found that TGF-β1- and LPS-induced fibrosis and inflammation were abrogated by Elp2 knockdown, which were intriguingly abolished by activating STAT3 phosphorylation using its activator of colivelin (Col). "
05/05/2022 - "In addition, administration of Colivelin and Nifuroxazide caused and blocked inflammation and apoptosis of BMSCs. "
10/01/2021 - "However, treatment with colivelin markedly reversed the inhibitory effects of Tofa on cell viability, cell apoptosis, oxidative stress and inflammation. "
01/01/2022 - "Experimental results in vivo and in vitro showed that wogonin could promote the recovery of motor function, improve the histopathological morphology, inhibit the activation of the STAT3 signal pathway, and reduce the neuronal inflammation and apoptosis in the rats with SCI. Activation of the STAT3 signal pathway by colivelin reversed the therapeutic effect of wogonin. "

01/01/2022 - "In addition, a tumor xenograft mouse model was used to examine the effect of B7H4 silencing (+/- Colivelin, an activator of STAT3) on tumor growth and macrophage polarization. "
03/19/2020 - "SHH-induced reduction of M2 polarization and tumor growth was blocked by colivelin treatment. "
02/22/2023 - "In addition, JAK2 and STAT3 expression were reduced by silencing of FANCD2, and STAT3 activator (colivelin) distinctly reversed tumor suppressor effects of FANCD2 silencing on osteosarcoma development. "
09/26/2023 - "Nonetheless, colivelin diminished the tumor-inhibiting impact of nuciferine, suggesting that nuciferine might partially impede the advancement of OSCC by suppressing the STAT3 signaling pathway. "
01/01/2021 - "The anti-tumor activity of fraxetin in PDA was functionally rescued by a STAT3 activator colivelin. "