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1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)urea

an alpha7nAChR agonist; structure in first source
Also Known As:
PNU 120596; PNU-120596; PNU120596
Networked: 30 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Uteshev, Victor V: 4 articles (01/2021 - 01/2013)
2. Gu, Xiaoping: 3 articles (01/2019 - 01/2015)
3. Ma, Zhengliang: 3 articles (01/2019 - 01/2015)
4. Zhang, Wei: 3 articles (01/2019 - 01/2015)
5. Damaj, M Imad: 3 articles (01/2018 - 01/2013)
6. Nikiforuk, Agnieszka: 2 articles (01/2021 - 01/2020)
7. Popik, Piotr: 2 articles (01/2021 - 01/2020)
8. Potasiewicz, Agnieszka: 2 articles (01/2021 - 01/2020)
9. Hou, Bailing: 2 articles (01/2019 - 01/2015)
10. Lei, Yishan: 2 articles (01/2019 - 01/2017)

Related Diseases

1. Schizophrenia (Dementia Praecox)
2. Memory Disorders (Memory Loss)
3. Cerebral Infarction
4. Inflammation (Inflammations)
01/01/2021 - "In the current study, we hypothesize that activating the cholinergic anti-inflammatory pathway at the level of the α7-nAChR with systemic administration of a partial agonist, GTS-21, and a PAM, PNU-120596, would reduce inflammation, eliminating the associated end organ damage in a mouse model of SLE with advanced disease. "
01/01/2019 - "The aim of our study was to evaluate the efficiency of α7-specific therapy at different stages of inflammation and to compare the effects of orthosteric agonist PNU282987 and type 2 positive allosteric modulator (PAM) PNU120596 in mice after a single injection of lipopolysaccharide (LPS). "
01/01/2021 - "We found that the increased plasma dsDNA autoantibodies, splenic and renal inflammation, renal injury and hypertension usually observed in SLE mice with advanced disease at 35 weeks of age were not altered by GTS-21 or PNU-120596. "
12/01/2020 - "PNU-120596 is a classical positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) and widely used to investigate the effect of α7 nAChR activation on several inflammation-associated diseases including rheumatoid arthritis, inflammatory bowel disease and cerebral ischemia. "
09/01/2012 - "We compared the anti-hyperalgesic and anti-inflammatory effects of the α7 nACh receptor agonist compound B with the positive allosteric modulator (PAM) PNU-120596 and the standard non-steroidal anti-inflammatory drug (NSAID), diclofenac, in rats with hind paw inflammation induced by either formalin, carrageenan or complete Freund's adjuvant (CFA). "
5. Hyperalgesia

Related Drugs and Biologics

1. Scopolamine (Hyoscine)
2. Cholinesterase Inhibitors (Anticholinesterases)
3. Donepezil (Aricept)
4. Glutamic Acid (Glutamate)
5. N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6. Memantine (Namenda)
7. Galantamine (Galanthamine)
8. Amphetamine (Amfetamine)
9. Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
10. PNU-282987

Related Therapies and Procedures

1. Therapeutics
2. Sutures (Suture)
3. Perioperative Period
4. Injections