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N- (1- ((6- fluoro- 2- naphthyl)methyl)pyrrolidin- 3- yl)- 2- (1- ((3- methyl- 1- oxidopyridin- 2- yl)carbonyl)piperidin- 4- ylidene)acetamide

inhibits binding of eotaxin-1 and RANTES to CCR-3 expressing cells; may have use as an anti-asthma agent; structure in first source

Also Known As:

YM 344031; YM-344031; YM344031

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dong, Chunyao: 1 article (01/2019)
2.	Sui, Yi: 1 article (01/2019)
3.	Sun, Xiaohong: 1 article (01/2019)
4.	Xu, Bing: 1 article (01/2019)
5.	Zhang, Yao: 1 article (01/2019)
6.	Ashikari, Masayuki: 1 article (02/2013)
7.	Mizutani, Takeshi: 1 article (02/2013)
8.	Nozaki, Miho: 1 article (02/2013)
9.	Ogura, Yuichiro: 1 article (02/2013)
10.	Tokoro, Mayumi: 1 article (02/2013)

Related Diseases

1.	Gliosis 01/01/2019 - "Treatment of 10-month-old APP/PS1 double-transgenic mice with YM344031 (50 mg/kg, b.i.d.) for two months resulted in dramatic decreases in β-amyloid deposition, tau hyperphosphorylation and synaptic loss in the forebrain, significant attenuation of microgliosis and astrogliosis, and marked improvement of spatial learning and memory performance compared with the vehicle-treated mice. "
2.	Macular Degeneration (Age-Related Maculopathy) 02/28/2013 - "Although our findings may warrant further investigation, YM-344031 may have potential as a new therapy for age-related macular degeneration."
3.	Inflammation (Inflammations) 01/27/2006 - "YM-344031 therefore has potential as a novel and orally available compound for the treatment of allergic inflammation, such as atopic dermatitis and asthma."
4.	Hypersensitivity (Allergy) 01/27/2006 - "Additionally, orally administered YM-344031 (100mg/kg) prevented both immediate- and late-phase allergic skin reactions in a mouse allergy model. "
5.	Atopic Dermatitis (Atopic Eczema) 01/27/2006 - "YM-344031 therefore has potential as a novel and orally available compound for the treatment of allergic inflammation, such as atopic dermatitis and asthma."

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