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(1,2- di(cyclopentadienyl)- 1,2- di(4- N,N- dimethylaminophenyl)ethanediyl)titanium dichloride

a titanocene with antineoplastic activity; structure in first source

Also Known As:

TITANOCENE X; bis(dimethylaminophenyl)-Cp2TiCl2

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - (1,2-di(cyclopentadienyl)-1,2-di(4-N,N-dimethylaminophenyl)ethanediyl)titanium dichloride: 2

Experts

1.	Strohfeldt, Katja: 2 articles (03/2006 - 11/2005)
2.	Sweeney, Nigel J: 2 articles (03/2006 - 11/2005)
3.	Tacke, Matthias: 2 articles (03/2006 - 11/2005)
4.	Queiroz, Mary L S: 1 article (03/2006)
5.	Ramos, Aline L: 1 article (03/2006)
6.	Rehmann, Franz-Josef K: 1 article (03/2006)
7.	Valadares, Marize C: 1 article (03/2006)
8.	Fiebig, Heinz-Herbert: 1 article (11/2005)
9.	Kelter, Gerhard: 1 article (11/2005)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2005 - "Titanocene Y with a mean IC50 value of 65.8 x 10 mol/l over the full panel of 36 cancer cell lines reaches the activity of cisplatin with 14.7 x 10 mol/l within a factor of 4, whereas Titanocene X and Z show significantly less cytotoxic activity. " 11/01/2005 - "The benzyl-substituted ansa-titanocenes [1,2-di(cyclopentadienyl)-1,2-di-(4-N,N-dimethylaminophenyl)ethanediyl] titanium dichloride (Titanocene X) and [1,2-di(cyclopentadienyl)-1,2-bis(m-dimethoxyphenyl)ethanediyl] titanium dichloride (Titanocene Z), and the benzyl-substituted unbridged titanocene bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene Y) were tested on the growth of a wide variety of tumor cells in vitro on a panel of 36 human tumor cell lines containing 14 different tumor types investigated in a cellular proliferation assay. "
2.	Ascites 03/18/2006 - "In parallel, TITANOCENE X prolonged, in a dose-dependent manner, the survival of mice inoculated with Ehrlich's ascites tumour. " 03/18/2006 - "The effects of a new titanocene compound with an ansa ligand in the cyclopentadienyl rings, the 1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride (TITANOCENE X), on the growth and differentiation of granulocyte-macrophage progenitor cells [colony-forming unit-granulocyte-macrophage (CFU-GM)] and Natural killer (NK) cell activity in Ehrlich's ascites tumour (EAT)-bearing mice were studied. "

Related Drugs and Biologics

1.	Titanium
2.	titanocene
3.	Ligands
4.	Cisplatin (Platino)
5.	Titanocene Y
6.	A-factor (Streptomyces)