podophyllic acid

natural product with antitumor effect

Also Known As:

podophyllinic acid; Naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, (5R,6R,7R,8R)-

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Che: 1 article (02/2005)
2.	Gao, Peilong: 1 article (02/2005)
3.	Jia, Zhengping: 1 article (02/2005)
4.	Yu, Jian: 1 article (02/2005)

Related Diseases

1.	Leukemia 02/01/2005 - "To study the effects of podophyllic acid on proliferation and apoptosis in human leukemia K562 cells. "
2.	Neoplasms (Cancer) 08/01/1968 - "Action of podophyllic acid on malignant tumors. " 08/01/1968 - "Action of podophyllic acid on malignant tumors. " 07/20/1967 - "[Synergic action of x-rays and of the ethylhydrazide of podophyllinic acid on a solid isologous tumor of the C3H mouse]." 08/01/1968 - "I. Distribution of tritiated podophyllic acid ethyl hydrazide in subcellular fractions of mouse mammary tumors." 10/15/1964 - "[THE DISTRIBUTION OF THE ANTIMITOTIC AGENT, ETHYLHYDRAZIDE OF PODOPHYLLIC ACID (SP-I 77) IN THE BODY AND IN HUMAN MALIGNANT TUMORS]."
3.	Lymphoid Leukemia 01/01/1989 - "The spin labeled derivatives of podophyllotoxin, 4-[4''-(2'',2'',6'',6''-tetramethyl-l''-piperidinyloxy)amino] -4'-demethylepipodophyllotoxin(GP-7,3) and N-podophyllic acid-N''-[4-(2,2,6,6-tetramethyl-l-piperidinyloxy)] thiosemicarbazide(GP-4,5) were synthesized and tested for their anticancer activity against the mouse solid tumors S180 and HepA in vivo, and the mouse lymphocytic leukemia L1210 and human stomach carcinoma SGC-7901 cells in vitro. " 11/01/1998 - "To examine the effect of the spin labeled derivatives of podophyllotoxin, N-podophyllic acid-N"-[4-(2,2,6,6-tetramethyl-1-piperidinyloxy)] thiosemicarbazide (GP4) and 4-[4"-(2",2",6",6"-tetramethyl-1"-piperidinyloxy) amino]-4'-demethylepipodophyllotoxin (GP7) on the cell cycle and macromolecular synthesis of human lymphoid leukemia Molt 4B cells in vitro. "
4.	Carcinoma (Carcinomatosis) 01/01/1989 - "The spin labeled derivatives of podophyllotoxin, 4-[4''-(2'',2'',6'',6''-tetramethyl-l''-piperidinyloxy)amino] -4'-demethylepipodophyllotoxin(GP-7,3) and N-podophyllic acid-N''-[4-(2,2,6,6-tetramethyl-l-piperidinyloxy)] thiosemicarbazide(GP-4,5) were synthesized and tested for their anticancer activity against the mouse solid tumors S180 and HepA in vivo, and the mouse lymphocytic leukemia L1210 and human stomach carcinoma SGC-7901 cells in vitro. " 06/01/1993 - "The spin-labeled derivative of podophyllotoxin, N'-podophyllic acid-N-[3-(2,2,5,5-tetramethyl pyrrolinenyloxy)] semicarbazide (GP-11), was synthesized and tested for its antitumor activity against mouse transplantable tumors, Sarcoma-180, Hepatoma-A, P388 leukemia and Ehrlich ascites carcinoma. "
5.	Sarcoma (Soft Tissue Sarcoma) 01/01/1971 - "Effect of podophyllic acid ethylhydrazide on virus-induced sarcomas in chicks."

Related Drugs and Biologics

1.	Podophyllotoxin (Condylox)
2.	Hydrazines
3.	Cytostatic Agents
4.	Antimitotic Agents
5.	Nucleic Acids
6.	Glucosides
7.	GP 4 (GP4)
8.	carbamylhydrazine (semicarbazide)
9.	thiosemicarbazide